Matches in SemOpenAlex for { <https://semopenalex.org/work/W2335846669> ?p ?o ?g. }
- W2335846669 endingPage "2208" @default.
- W2335846669 startingPage "2200" @default.
- W2335846669 abstract "We report that JadX, a protein of previously undetermined function coded for in the jadomycin biosynthetic gene cluster of Streptomyces venezuelae ISP5230, affects both chloramphenicol and jadomycin production levels in blocked mutants. Characterization of recombinant JadX through protein-ligand interactions by chemical shift perturbation and WaterLOGSY NMR spectroscopy resulted in the observation of binding between JadX and a series of jadomycins and between JadX and chloramphenicol, another natural product produced by S. venezuelae ISP5230. These results suggest JadX to be an unusual class of natural product binding protein involved in binding structurally disparate natural products. The ability for JadX to bind two different natural products in vitro and the ability to affect production of these secondary metabolites in vivo suggest a potential role in regulation or signaling. This is the first example of functional characterization of these JadX-like proteins, and provides insight into a previously unobserved regulatory process." @default.
- W2335846669 created "2016-06-24" @default.
- W2335846669 creator A5013611568 @default.
- W2335846669 creator A5014011167 @default.
- W2335846669 creator A5019873259 @default.
- W2335846669 creator A5055855760 @default.
- W2335846669 creator A5058276184 @default.
- W2335846669 creator A5076195605 @default.
- W2335846669 date "2016-02-10" @default.
- W2335846669 modified "2023-10-12" @default.
- W2335846669 title "JadX is a Disparate Natural Product Binding Protein" @default.
- W2335846669 cites W1209134892 @default.
- W2335846669 cites W1539580523 @default.
- W2335846669 cites W1555135632 @default.
- W2335846669 cites W1776559329 @default.
- W2335846669 cites W1827213771 @default.
- W2335846669 cites W1964749480 @default.
- W2335846669 cites W1968448329 @default.
- W2335846669 cites W1970712032 @default.
- W2335846669 cites W1973025873 @default.
- W2335846669 cites W1982418282 @default.
- W2335846669 cites W2001680248 @default.
- W2335846669 cites W2007835427 @default.
- W2335846669 cites W2012221059 @default.
- W2335846669 cites W2012960603 @default.
- W2335846669 cites W2019329463 @default.
- W2335846669 cites W2019681366 @default.
- W2335846669 cites W2022299968 @default.
- W2335846669 cites W2022613179 @default.
- W2335846669 cites W2029174255 @default.
- W2335846669 cites W2030849279 @default.
- W2335846669 cites W2035133853 @default.
- W2335846669 cites W2039811523 @default.
- W2335846669 cites W2039947832 @default.
- W2335846669 cites W2040025293 @default.
- W2335846669 cites W2061151008 @default.
- W2335846669 cites W2066694874 @default.
- W2335846669 cites W2069700683 @default.
- W2335846669 cites W2072535406 @default.
- W2335846669 cites W2076630944 @default.
- W2335846669 cites W2081418090 @default.
- W2335846669 cites W2085441805 @default.
- W2335846669 cites W2095035289 @default.
- W2335846669 cites W2105480547 @default.
- W2335846669 cites W2108153887 @default.
- W2335846669 cites W2108605192 @default.
- W2335846669 cites W2109939279 @default.
- W2335846669 cites W2121356063 @default.
- W2335846669 cites W2125162757 @default.
- W2335846669 cites W2127639267 @default.
- W2335846669 cites W2131845456 @default.
- W2335846669 cites W2132180320 @default.
- W2335846669 cites W2133504807 @default.
- W2335846669 cites W2144678314 @default.
- W2335846669 cites W2152651890 @default.
- W2335846669 cites W2153584471 @default.
- W2335846669 cites W2155254049 @default.
- W2335846669 cites W2159865967 @default.
- W2335846669 cites W2221177433 @default.
- W2335846669 cites W2326526703 @default.
- W2335846669 cites W2463835702 @default.
- W2335846669 cites W2797276060 @default.
- W2335846669 cites W4234428193 @default.
- W2335846669 cites W60468736 @default.
- W2335846669 doi "https://doi.org/10.1021/jacs.5b11286" @default.
- W2335846669 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26814718" @default.
- W2335846669 hasPublicationYear "2016" @default.
- W2335846669 type Work @default.
- W2335846669 sameAs 2335846669 @default.
- W2335846669 citedByCount "9" @default.
- W2335846669 countsByYear W23358466692016 @default.
- W2335846669 countsByYear W23358466692017 @default.
- W2335846669 countsByYear W23358466692018 @default.
- W2335846669 countsByYear W23358466692022 @default.
- W2335846669 crossrefType "journal-article" @default.
- W2335846669 hasAuthorship W2335846669A5013611568 @default.
- W2335846669 hasAuthorship W2335846669A5014011167 @default.
- W2335846669 hasAuthorship W2335846669A5019873259 @default.
- W2335846669 hasAuthorship W2335846669A5055855760 @default.
- W2335846669 hasAuthorship W2335846669A5058276184 @default.
- W2335846669 hasAuthorship W2335846669A5076195605 @default.
- W2335846669 hasBestOaLocation W23358466692 @default.
- W2335846669 hasConcept C104317684 @default.
- W2335846669 hasConcept C107824862 @default.
- W2335846669 hasConcept C116569031 @default.
- W2335846669 hasConcept C14036430 @default.
- W2335846669 hasConcept C143065580 @default.
- W2335846669 hasConcept C150194340 @default.
- W2335846669 hasConcept C170493617 @default.
- W2335846669 hasConcept C171852809 @default.
- W2335846669 hasConcept C185592680 @default.
- W2335846669 hasConcept C195286587 @default.
- W2335846669 hasConcept C2779396153 @default.
- W2335846669 hasConcept C40767141 @default.
- W2335846669 hasConcept C51639874 @default.
- W2335846669 hasConcept C553089730 @default.
- W2335846669 hasConcept C55493867 @default.
- W2335846669 hasConcept C70721500 @default.