Matches in SemOpenAlex for { <https://semopenalex.org/work/W2335882509> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W2335882509 endingPage "AB110" @default.
- W2335882509 startingPage "AB110" @default.
- W2335882509 abstract "Viral infections, most commonly rhinoviruses (RV), are the most frequent cause of respiratory tract illnesses (RTIs) and wheezing in preschool children. There are three RV species, A, B, and C, and RV-C has recently been associated with more severe RTIs in children. We assessed the relationships among viral etiology and illness severity in children enrolled in the Azithromycin for Preventing the Development of Upper Respiratory Tract Illness into Lower Respiratory Tract Symptoms (APRIL) study. Nasal samples (n=1983) were collected at randomization and during RTIs from preschool-age children enrolled in APRIL, and were analyzed using PCR and partial sequencing to identify adenoviruses, coronaviruses, bocavirus, enterovirus, rhinoviruses (A,B,C), influenza, parainfluenza, respiratory syncytial virus and metapneumovirus. Relationships among viral etiology and illness severity were analyzed by discrete survival. Viruses were detected in 87% of RTIs that led to treatment failure (TF), 78% of non-TF RTIs, and 38% of non-RTI samples. RV-A (22%) and RV-C (25%) were most commonly detected during RTIs. During the APRIL study, RV-C was detected in 36% of TFs. Patients with RTIs induced by RV-C had significantly increased risk of TF (RV-C vs. no virus, HR 2.4; p=0.01). Infections with RV-A (HR 1.6; p=0.22), RV-B (HR 1.0; p=0.97) or other viruses (HR 1.8; p=0.10) did not significantly increase risk of TF. RV-A and C were the most common viruses detected during RTIs in preschool aged children enrolled in the APRIL study. Infection with RV-C was associated with increased risk of treatment failure. Analyses of interactions with APRIL treatment are ongoing." @default.
- W2335882509 created "2016-06-24" @default.
- W2335882509 creator A5013823897 @default.
- W2335882509 creator A5015707215 @default.
- W2335882509 creator A5028601216 @default.
- W2335882509 creator A5031055479 @default.
- W2335882509 creator A5044705183 @default.
- W2335882509 creator A5056700648 @default.
- W2335882509 creator A5057890262 @default.
- W2335882509 creator A5058884153 @default.
- W2335882509 creator A5069917433 @default.
- W2335882509 creator A5061765002 @default.
- W2335882509 date "2016-02-01" @default.
- W2335882509 modified "2023-10-09" @default.
- W2335882509 title "Rhinovirus C Infections Are Associated with Treatment Failure in Preschool Children with Recurrent Wheezing" @default.
- W2335882509 doi "https://doi.org/10.1016/j.jaci.2015.12.485" @default.
- W2335882509 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7172248" @default.
- W2335882509 hasPublicationYear "2016" @default.
- W2335882509 type Work @default.
- W2335882509 sameAs 2335882509 @default.
- W2335882509 citedByCount "0" @default.
- W2335882509 crossrefType "journal-article" @default.
- W2335882509 hasAuthorship W2335882509A5013823897 @default.
- W2335882509 hasAuthorship W2335882509A5015707215 @default.
- W2335882509 hasAuthorship W2335882509A5028601216 @default.
- W2335882509 hasAuthorship W2335882509A5031055479 @default.
- W2335882509 hasAuthorship W2335882509A5044705183 @default.
- W2335882509 hasAuthorship W2335882509A5056700648 @default.
- W2335882509 hasAuthorship W2335882509A5057890262 @default.
- W2335882509 hasAuthorship W2335882509A5058884153 @default.
- W2335882509 hasAuthorship W2335882509A5061765002 @default.
- W2335882509 hasAuthorship W2335882509A5069917433 @default.
- W2335882509 hasBestOaLocation W23358825091 @default.
- W2335882509 hasConcept C187212893 @default.
- W2335882509 hasConcept C203014093 @default.
- W2335882509 hasConcept C2522874641 @default.
- W2335882509 hasConcept C2779278377 @default.
- W2335882509 hasConcept C71924100 @default.
- W2335882509 hasConceptScore W2335882509C187212893 @default.
- W2335882509 hasConceptScore W2335882509C203014093 @default.
- W2335882509 hasConceptScore W2335882509C2522874641 @default.
- W2335882509 hasConceptScore W2335882509C2779278377 @default.
- W2335882509 hasConceptScore W2335882509C71924100 @default.
- W2335882509 hasIssue "2" @default.
- W2335882509 hasLocation W23358825091 @default.
- W2335882509 hasLocation W23358825092 @default.
- W2335882509 hasOpenAccess W2335882509 @default.
- W2335882509 hasPrimaryLocation W23358825091 @default.
- W2335882509 hasRelatedWork W1506200166 @default.
- W2335882509 hasRelatedWork W1995515455 @default.
- W2335882509 hasRelatedWork W2048182022 @default.
- W2335882509 hasRelatedWork W2080531066 @default.
- W2335882509 hasRelatedWork W2604872355 @default.
- W2335882509 hasRelatedWork W2748952813 @default.
- W2335882509 hasRelatedWork W2899084033 @default.
- W2335882509 hasRelatedWork W3031052312 @default.
- W2335882509 hasRelatedWork W3032375762 @default.
- W2335882509 hasRelatedWork W3108674512 @default.
- W2335882509 hasVolume "137" @default.
- W2335882509 isParatext "false" @default.
- W2335882509 isRetracted "false" @default.
- W2335882509 magId "2335882509" @default.
- W2335882509 workType "article" @default.