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• W2335897113 abstract "OBJECTIVE To evaluate the efficacy of a portable, wearable, wireless artificial pancreas system (the Diabetes Assistant [DiAs] running the Unified Safety System) on glucose control at home in overnight-only and 24/7 closed-loop control (CLC) modes in patients with type 1 diabetes. RESEARCH DESIGN AND METHODS At six clinical centers in four countries, 30 participants 18–66 years old with type 1 diabetes (43% female, 96% non-Hispanic white, median type 1 diabetes duration 19 years, median A1C 7.3%) completed the study. The protocol included a 2-week baseline sensor-augmented pump (SAP) period followed by 2 weeks of overnight-only CLC and 2 weeks of 24/7 CLC at home. Glucose control during CLC was compared with the baseline SAP. RESULTS Glycemic control parameters for overnight-only CLC were improved during the nighttime period compared with baseline for hypoglycemia (time &lt;70 mg/dL, primary end point median 1.1% vs. 3.0%; P &lt; 0.001), time in target (70–180 mg/dL: 75% vs. 61%; P &lt; 0.001), and glucose variability (coefficient of variation: 30% vs. 36%; P &lt; 0.001). Similar improvements for day/night combined were observed with 24/7 CLC compared with baseline: 1.7% vs. 4.1%, P &lt; 0.001; 73% vs. 65%, P &lt; 0.001; and 34% vs. 38%, P &lt; 0.001, respectively. CONCLUSIONS CLC running on a smartphone (DiAs) in the home environment was safe and effective. Overnight-only CLC reduced hypoglycemia and increased time in range overnight and increased time in range during the day; 24/7 CLC reduced hypoglycemia and increased time in range both overnight and during the day. Compared with overnight-only CLC, 24/7 CLC provided additional hypoglycemia protection during the day." @default.
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• W2335897113 date "2016-03-16" @default.
• W2335897113 modified "2023-10-17" @default.
• W2335897113 title "Multinational Home Use of Closed-Loop Control Is Safe and Effective" @default.
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• W2335897113 doi "https://doi.org/10.2337/dc15-2468" @default.
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