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- W2335972438 abstract "Introduction: There is increasing evidence that peri-operative blood loss and blood transfusions are associated with poorer short- and long-term outcomes in patients undergoing surgery. The aim was to ascertain the effect of red blood cell transfusion (RBCT) and blood loss on overall survival (OS) and recurrence free survival (RFS) on patients undergoing a hepatectomy for colorectal liver metastases (CRLM). A secondary outcome was to identify factors predisposing to blood loss/RBCT. Methods: A retrospective review of a prospectively collected patient database, between 2005–2012 was undertaken. Overall survival (OS) and recurrence free survival (RFS) were assessed using the Kaplan–Meier and Cox regression methods. The predictive significance of certain clinicopathological variables were measured using univariate and multivariate regression analyses. Results: There were 690 patients included in this study, of whom 446 (68.1%) were males. The median age was 68years and median follow up was 33 months. Patients who received RBCT had a lower median survival (41 vs 49 months, p = 0.04) to those who did not undergo RBCT. Similarly the median RFS was lower for patients who received RBCT than those who did not (9 vs 17 months, p = 0.014). However, blood loss alone was not related to OS or RFS. Pre-operative predictors of transfusion included pre-operative anaemia, size of the largest tumour and primary tumour location. Conclusions: RBCT is associated with significantly poorer OS and RFS although blood loss alone does not impact survival outcomes. The main predictors of RBCT were pre-operative anaemia, size of the largest tumour and location of the primary tumour." @default.
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- W2335972438 date "2016-04-01" @default.
- W2335972438 modified "2023-10-17" @default.
- W2335972438 title "The long term impact of peri-operative red blood cell transfusions in patients undergoing hepatectomy for colorectal liver metastases (CRLM)" @default.
- W2335972438 doi "https://doi.org/10.1016/j.hpb.2016.02.446" @default.
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