FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2335992016> ?p ?o ?g. }

• W2335992016 endingPage "1012" @default.
• W2335992016 startingPage "991" @default.
• W2335992016 abstract "Aims: Oxidants play a critical role in the pathogenesis of acute lung injury (ALI). Nox3 is a novel member of the NADPH oxidase (Nox) family of oxidant-generating enzymes, which our laboratory had previously identified to be induced in the lungs of TLR4−/− mice. However, the physiologic role of Nox3 induction in lungs and its precise relationship to TLR4 are unknown. Furthermore, the cell compartment involved and the signaling mechanisms of Nox3 induction are unknown. Results: We identified that Nox3 is regulated by heat shock protein 70 (Hsp70) signaling via a TLR4-Trif-signal transducer and activator of transcription 3 (Stat3) pathway and that Nox3 induction leads to increased oxidant injury and death in mice and lung endothelial cells. We generated Nox3−/−/TLR4−/− double knockout mice, endothelial-targeting lentiviral silencing constructs, and endothelial-targeted Stat3−/− mice to specifically demonstrate that Nox3 induction is responsible for the pro-oxidant, proapoptotic phenotype of TLR4−/− mice. We also show that an endothelial Hsp70-TLR4-Trif-Stat3 axis is required to suppress deleterious Nox3 induction. Innovation: To date, a physiologic role for Nox3 in oxidant-induced ALI has not been identified. In addition, we generated unique double knockout mice and endothelial-targeted lentiviral silencing constructs to specifically demonstrate the role of a TLR4 signaling pathway in regulating pro-oxidant generation. Conclusions: We identified an endothelial TLR4-Trif antioxidant pathway that leads to the inhibition of a novel NADPH oxidase, Nox3, in lungs and lung endothelial cells. We also identified the role of a TLR4 ligand, Hsp70, in suppressing Nox3 in basal and pro-oxidant conditions. These studies identify potentially new therapeutic targets in oxidant-induced ALI. Antioxid. Redox Signal. 24, 991–1012." @default.
• W2335992016 created "2016-06-24" @default.
• W2335992016 creator A5003310617 @default.
• W2335992016 creator A5006751803 @default.
• W2335992016 creator A5015024651 @default.
• W2335992016 creator A5016216116 @default.
• W2335992016 creator A5041011399 @default.
• W2335992016 creator A5074774970 @default.
• W2335992016 date "2016-06-10" @default.
• W2335992016 modified "2023-09-26" @default.
• W2335992016 title "An Endothelial Hsp70-TLR4 Axis Limits Nox3 Expression and Protects Against Oxidant Injury in Lungs" @default.
• W2335992016 cites W1528644208 @default.
• W2335992016 cites W1581447730 @default.
• W2335992016 cites W1585390661 @default.
• W2335992016 cites W1780350718 @default.
• W2335992016 cites W1989615889 @default.
• W2335992016 cites W1991416826 @default.
• W2335992016 cites W1998209096 @default.
• W2335992016 cites W2009895452 @default.
• W2335992016 cites W2010154445 @default.
• W2335992016 cites W2010594655 @default.
• W2335992016 cites W2011964721 @default.
• W2335992016 cites W2022971967 @default.
• W2335992016 cites W2024745635 @default.
• W2335992016 cites W2032028059 @default.
• W2335992016 cites W2034400796 @default.
• W2335992016 cites W2036336318 @default.
• W2335992016 cites W2038295164 @default.
• W2335992016 cites W2056269088 @default.
• W2335992016 cites W2057397798 @default.
• W2335992016 cites W2058060087 @default.
• W2335992016 cites W2064820057 @default.
• W2335992016 cites W2067183392 @default.
• W2335992016 cites W2070297535 @default.
• W2335992016 cites W2080335191 @default.
• W2335992016 cites W2087712400 @default.
• W2335992016 cites W2094026960 @default.
• W2335992016 cites W2098659547 @default.
• W2335992016 cites W2102619095 @default.
• W2335992016 cites W2109095930 @default.
• W2335992016 cites W2116807191 @default.
• W2335992016 cites W2125242137 @default.
• W2335992016 cites W2132146723 @default.
• W2335992016 cites W2152698731 @default.
• W2335992016 cites W2156504947 @default.
• W2335992016 cites W2161297853 @default.
• W2335992016 cites W2161615911 @default.
• W2335992016 cites W2190333148 @default.
• W2335992016 cites W2402899981 @default.
• W2335992016 doi "https://doi.org/10.1089/ars.2015.6505" @default.
• W2335992016 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4922010" @default.
• W2335992016 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26905942" @default.
• W2335992016 hasPublicationYear "2016" @default.
• W2335992016 type Work @default.
• W2335992016 sameAs 2335992016 @default.
• W2335992016 citedByCount "14" @default.
• W2335992016 countsByYear W23359920162016 @default.
• W2335992016 countsByYear W23359920162018 @default.
• W2335992016 countsByYear W23359920162019 @default.
• W2335992016 countsByYear W23359920162021 @default.
• W2335992016 countsByYear W23359920162022 @default.
• W2335992016 countsByYear W23359920162023 @default.
• W2335992016 crossrefType "journal-article" @default.
• W2335992016 hasAuthorship W2335992016A5003310617 @default.
• W2335992016 hasAuthorship W2335992016A5006751803 @default.
• W2335992016 hasAuthorship W2335992016A5015024651 @default.
• W2335992016 hasAuthorship W2335992016A5016216116 @default.
• W2335992016 hasAuthorship W2335992016A5041011399 @default.
• W2335992016 hasAuthorship W2335992016A5074774970 @default.
• W2335992016 hasBestOaLocation W23359920162 @default.
• W2335992016 hasConcept C123012128 @default.
• W2335992016 hasConcept C126322002 @default.
• W2335992016 hasConcept C136449434 @default.
• W2335992016 hasConcept C202751555 @default.
• W2335992016 hasConcept C203014093 @default.
• W2335992016 hasConcept C2776070231 @default.
• W2335992016 hasConcept C2776709828 @default.
• W2335992016 hasConcept C2777714996 @default.
• W2335992016 hasConcept C2778923194 @default.
• W2335992016 hasConcept C2779719074 @default.
• W2335992016 hasConcept C2779765511 @default.
• W2335992016 hasConcept C2780672939 @default.
• W2335992016 hasConcept C43929388 @default.
• W2335992016 hasConcept C48349386 @default.
• W2335992016 hasConcept C502942594 @default.
• W2335992016 hasConcept C55493867 @default.
• W2335992016 hasConcept C62478195 @default.
• W2335992016 hasConcept C71924100 @default.
• W2335992016 hasConcept C86803240 @default.
• W2335992016 hasConcept C8891405 @default.
• W2335992016 hasConcept C95444343 @default.
• W2335992016 hasConceptScore W2335992016C123012128 @default.
• W2335992016 hasConceptScore W2335992016C126322002 @default.
• W2335992016 hasConceptScore W2335992016C136449434 @default.
• W2335992016 hasConceptScore W2335992016C202751555 @default.
• W2335992016 hasConceptScore W2335992016C203014093 @default.
• W2335992016 hasConceptScore W2335992016C2776070231 @default.
• W2335992016 hasConceptScore W2335992016C2776709828 @default.

• next