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- W2336005229 abstract "Excess glutamate release from the presynaptic membrane has been thought to be the major cause of ischemic neuronal death. Although both CA1 and CA3 pyramidal neurons receive presynaptic glutamate input, transient cerebral ischemia induces CA1 neurons to die while CA3 neurons remain relatively intact. This suggests that changes in the properties of pyramidal cells may be the main cause related to ischemic neuronal death. Our previous studies have shown that the densities of dendritic spines and asymmetric synapses in the CA1 area are increased at 12 h and 24 h after ischemia. In the present study, we investigated changes in synaptic structures in the CA3 area and compared the expression of glutamate receptors in the CA1 and CA3 hippocampal regions of rats after ischemia. Our results demonstrated that the NR2B/NR2A ratio became larger after ischemia although the expression of both the NR2B subunit (activation of apoptotic pathway) and NR2A subunit (activation of survival pathway) decreased in the CA1 area from 6 h to 48 h after reperfusion. Furthermore, expression of the GluR2 subunit (calcium impermeable) of the AMPA receptor class significantly decreased while the GluR1 subunit (calcium permeable) remained unchanged at the same examined reperfusion times, which subsequently caused an increase in the GluR1/GluR2 ratio. Despite these notable differences in subunit expression, there were no obvious changes in the density of synapses or expression of NMDAR and AMPAR subunits in the CA3 area after ischemia. These results suggest that delayed CA1 neuronal death may be related to the dramatic fluctuation in the synaptic structure and relative upregulation of NR2B and GluR1 subunits induced by transient global ischemia." @default.
- W2336005229 created "2016-06-24" @default.
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- W2336005229 date "2016-07-01" @default.
- W2336005229 modified "2023-09-26" @default.
- W2336005229 title "Changes in synaptic plasticity and expression of glutamate receptor subunits in the CA1 and CA3 areas of the hippocampus after transient global ischemia" @default.
- W2336005229 cites W1597908762 @default.
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- W2336005229 cites W1798313689 @default.
- W2336005229 cites W1881368483 @default.
- W2336005229 cites W1918304474 @default.
- W2336005229 cites W1938071689 @default.
- W2336005229 cites W1966556202 @default.
- W2336005229 cites W1967117930 @default.
- W2336005229 cites W1969417742 @default.
- W2336005229 cites W1974316629 @default.
- W2336005229 cites W1977865087 @default.
- W2336005229 cites W1978577318 @default.
- W2336005229 cites W1982892406 @default.
- W2336005229 cites W1983600962 @default.
- W2336005229 cites W1983687430 @default.
- W2336005229 cites W1984841129 @default.
- W2336005229 cites W1984858305 @default.
- W2336005229 cites W1984865310 @default.
- W2336005229 cites W1990527115 @default.
- W2336005229 cites W1992925059 @default.
- W2336005229 cites W1995667177 @default.
- W2336005229 cites W2000215200 @default.
- W2336005229 cites W2000320185 @default.
- W2336005229 cites W2002266960 @default.
- W2336005229 cites W2005354224 @default.
- W2336005229 cites W2006406301 @default.
- W2336005229 cites W2006815009 @default.
- W2336005229 cites W2013739229 @default.
- W2336005229 cites W2016756702 @default.
- W2336005229 cites W2020622209 @default.
- W2336005229 cites W2037221789 @default.
- W2336005229 cites W2037337146 @default.
- W2336005229 cites W2037714880 @default.
- W2336005229 cites W2037852973 @default.
- W2336005229 cites W2038492152 @default.
- W2336005229 cites W2047393288 @default.
- W2336005229 cites W2049409276 @default.
- W2336005229 cites W2052330193 @default.
- W2336005229 cites W2056607057 @default.
- W2336005229 cites W2059117412 @default.
- W2336005229 cites W2062853844 @default.
- W2336005229 cites W2065848862 @default.
- W2336005229 cites W2070536046 @default.
- W2336005229 cites W2073508793 @default.
- W2336005229 cites W2078167209 @default.
- W2336005229 cites W2084331785 @default.
- W2336005229 cites W2088912287 @default.
- W2336005229 cites W2095484045 @default.
- W2336005229 cites W2103490092 @default.
- W2336005229 cites W2103762808 @default.
- W2336005229 cites W2107099794 @default.
- W2336005229 cites W2112215250 @default.
- W2336005229 cites W2115296629 @default.
- W2336005229 cites W2118740391 @default.
- W2336005229 cites W2120695893 @default.
- W2336005229 cites W2121239869 @default.
- W2336005229 cites W2126579241 @default.
- W2336005229 cites W2131475149 @default.
- W2336005229 cites W2132844263 @default.
- W2336005229 cites W2132971431 @default.
- W2336005229 cites W2146521940 @default.
- W2336005229 cites W2148714108 @default.
- W2336005229 cites W2148908036 @default.
- W2336005229 cites W2152696633 @default.
- W2336005229 cites W2154258102 @default.
- W2336005229 cites W2158715353 @default.
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- W2336005229 cites W2341565990 @default.
- W2336005229 cites W2418351874 @default.
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- W2336005229 doi "https://doi.org/10.1016/j.neuroscience.2016.04.011" @default.
- W2336005229 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27090818" @default.
- W2336005229 hasPublicationYear "2016" @default.
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