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- W2336013252 abstract "Significance Cranial irradiation used during the clinical management of brain cancer is associated with severe cognitive decline and represents a particular concern for pediatric cancer survivors. Irradiation triggers neuroinflammation and compromises the structure of neurons, factors that are contributory if not causal to radiation-induced cognitive dysfunction. Our previous data have shown that intrahippocampal transplantation of human neural stem cells (hNSCs) could ameliorate radiation-induced behavioral deficits and improve neuronal plasticity. These beneficial neurocognitive effects were hypothesized to act through a trophic support mechanism involving the secretion of microvesicles acting on host neuronal circuitry. Here we show that cranial grafting of hNSC-derived microvesicles reverses or prevents radiation-induced cognitive dysfunction through mechanisms involving the suppression of inflammation and the preservation of host neuronal architecture." @default.
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- W2336013252 date "2016-04-04" @default.
- W2336013252 modified "2023-10-18" @default.
- W2336013252 title "Cranial grafting of stem cell-derived microvesicles improves cognition and reduces neuropathology in the irradiated brain" @default.
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- W2336013252 doi "https://doi.org/10.1073/pnas.1521668113" @default.
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