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- W2336052222 abstract "Background: It is difficult to predict the outcomes of patients undergoing resection for hepatocellular carcinoma (HCC). Different staging systems and guidelines have been devised, with disparate results. The aim of this study was to create a new nomogram to predict individual survival after hepatectomy for HCC. Methods: Based on the 'Hepatocellular Carcinoma: Eastern & Western Experiences Network', data from 2,046 patients who underwent HCC resections at 10 worldwide centers were reviewed. Patient survival was analyzed, with respect to significant prognostic factors, and dedicated Cox regression analysis was used to construct a unique nomogram and counter-plots to predict prognosis at 5-year. Results: The new nomograms built on the results of the multivariate analyses, which showed that the independent predictors were tumor size, tumor number, vascular invasion, cirrhosis, preoperative bilirubin value, and esophageal varices showed good calibration and discriminatory abilities with C-index value of 0.62 (95% CI, 0.59–0.69) and 0.61 (95% CI, 0.56 to 0.64) for overall and disease-free survival respectively. The 5-year overall survival contour-plots showed that the presence of vascular invasion was associated with decreased survival probability, regardless of the tumor number or size. Cirrhosis and varices were equally associated with decreased survival, according to the tumor number or size. Conclusions: In the era of personalized medicine, these nomograms accurately predict individual prognosis after HCC resection. They should be prospectively validated with the aim to change current practices that limit the chance of a cure for a significant number of patients." @default.
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- W2336052222 date "2016-04-01" @default.
- W2336052222 modified "2023-10-18" @default.
- W2336052222 title "Predicting individual survival after hepatectomy for hepatocellular carcinoma: A novel nomogram from the 'HCC East & West Study Group'" @default.
- W2336052222 doi "https://doi.org/10.1016/j.hpb.2016.02.022" @default.
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