FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2336060235> ?p ?o ?g. }

• W2336060235 endingPage "1796" @default.
• W2336060235 startingPage "1785" @default.
• W2336060235 abstract "The mitogen-activated protein kinase (MAPK) pathway is constantly activated in Langerhans cell histiocytosis (LCH). Mutations of the downstream kinases BRAF and MAP2K1 mediate this activation in a subset of LCH lesions. In this study, we attempted to identify other mutations which may explain the MAPK activation in nonmutated BRAF and MAP2K1 LCH lesions. We analysed 26 pulmonary and 37 nonpulmonary LCH lesions for the presence of BRAF , MAP2K1 , NRAS and KRAS mutations. Grossly normal lung tissue from 10 smoker patients was used as control. Patient spontaneous outcomes were concurrently assessed. BRAF V600E mutations were observed in 50% and 38% of the pulmonary and nonpulmonary LCH lesions, respectively. 40% of pulmonary LCH lesions harboured NRAS Q61K / R mutations, whereas no NRAS mutations were identified in nonpulmonary LCH biopsies or in lung tissue control. In seven out of 11 NRAS Q61K / R -mutated pulmonary LCH lesions, BRAF V600 E mutations were also present. Separately genotyping each CD1a-positive area from the same pulmonary LCH lesion demonstrated that these concurrent BRAF and NRAS mutations were carried by different cell clones. NRAS Q61K / R mutations activated both the MAPK and AKT (protein kinase B) pathways. In the univariate analysis, the presence of concurrent BRAF V600E and NRAS Q61K / R mutations was significantly associated with patient outcome. These findings highlight the importance of NRAS genotyping of pulmonary LCH lesions because the use of BRAF inhibitors in this context may lead to paradoxical disease progression. These patients might benefit from MAPK kinase inhibitor-based treatments." @default.
• W2336060235 created "2016-06-24" @default.
• W2336060235 creator A5007042449 @default.
• W2336060235 creator A5015744390 @default.
• W2336060235 creator A5025478490 @default.
• W2336060235 creator A5030009487 @default.
• W2336060235 creator A5033209457 @default.
• W2336060235 creator A5040881615 @default.
• W2336060235 creator A5046348541 @default.
• W2336060235 creator A5052673276 @default.
• W2336060235 creator A5060931224 @default.
• W2336060235 creator A5071537878 @default.
• W2336060235 creator A5087449110 @default.
• W2336060235 date "2016-04-13" @default.
• W2336060235 modified "2023-10-17" @default.
• W2336060235 title "Recurrent<i>NRAS</i>mutations in pulmonary Langerhans cell histiocytosis" @default.
• W2336060235 cites W1846586690 @default.
• W2336060235 cites W1873776953 @default.
• W2336060235 cites W1974223566 @default.
• W2336060235 cites W1974889077 @default.
• W2336060235 cites W1989888272 @default.
• W2336060235 cites W1990011632 @default.
• W2336060235 cites W1990412304 @default.
• W2336060235 cites W1990426510 @default.
• W2336060235 cites W1994697297 @default.
• W2336060235 cites W2031134972 @default.
• W2336060235 cites W2032211985 @default.
• W2336060235 cites W2035001481 @default.
• W2336060235 cites W2040518723 @default.
• W2336060235 cites W2041213818 @default.
• W2336060235 cites W2041958591 @default.
• W2336060235 cites W2048765718 @default.
• W2336060235 cites W2054218124 @default.
• W2336060235 cites W2055389755 @default.
• W2336060235 cites W2059581635 @default.
• W2336060235 cites W2060317877 @default.
• W2336060235 cites W2062088207 @default.
• W2336060235 cites W2068170146 @default.
• W2336060235 cites W2081151196 @default.
• W2336060235 cites W2086751758 @default.
• W2336060235 cites W2093884670 @default.
• W2336060235 cites W2095514651 @default.
• W2336060235 cites W2100681411 @default.
• W2336060235 cites W2105317859 @default.
• W2336060235 cites W2105660237 @default.
• W2336060235 cites W2106451155 @default.
• W2336060235 cites W2112967018 @default.
• W2336060235 cites W2124794993 @default.
• W2336060235 cites W2129718853 @default.
• W2336060235 cites W2147638236 @default.
• W2336060235 cites W2152044539 @default.
• W2336060235 cites W2157696440 @default.
• W2336060235 cites W2161282095 @default.
• W2336060235 cites W2169829719 @default.
• W2336060235 cites W2170639557 @default.
• W2336060235 cites W2248712381 @default.
• W2336060235 cites W2322086669 @default.
• W2336060235 cites W2325716909 @default.
• W2336060235 doi "https://doi.org/10.1183/13993003.01677-2015" @default.
• W2336060235 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27076591" @default.
• W2336060235 hasPublicationYear "2016" @default.
• W2336060235 type Work @default.
• W2336060235 sameAs 2336060235 @default.
• W2336060235 citedByCount "79" @default.
• W2336060235 countsByYear W23360602352016 @default.
• W2336060235 countsByYear W23360602352017 @default.
• W2336060235 countsByYear W23360602352018 @default.
• W2336060235 countsByYear W23360602352019 @default.
• W2336060235 countsByYear W23360602352020 @default.
• W2336060235 countsByYear W23360602352021 @default.
• W2336060235 countsByYear W23360602352022 @default.
• W2336060235 countsByYear W23360602352023 @default.
• W2336060235 crossrefType "journal-article" @default.
• W2336060235 hasAuthorship W2336060235A5007042449 @default.
• W2336060235 hasAuthorship W2336060235A5015744390 @default.
• W2336060235 hasAuthorship W2336060235A5025478490 @default.
• W2336060235 hasAuthorship W2336060235A5030009487 @default.
• W2336060235 hasAuthorship W2336060235A5033209457 @default.
• W2336060235 hasAuthorship W2336060235A5040881615 @default.
• W2336060235 hasAuthorship W2336060235A5046348541 @default.
• W2336060235 hasAuthorship W2336060235A5052673276 @default.
• W2336060235 hasAuthorship W2336060235A5060931224 @default.
• W2336060235 hasAuthorship W2336060235A5071537878 @default.
• W2336060235 hasAuthorship W2336060235A5087449110 @default.
• W2336060235 hasBestOaLocation W23360602351 @default.
• W2336060235 hasConcept C121608353 @default.
• W2336060235 hasConcept C126322002 @default.
• W2336060235 hasConcept C142724271 @default.
• W2336060235 hasConcept C184235292 @default.
• W2336060235 hasConcept C21790070 @default.
• W2336060235 hasConcept C2781187634 @default.
• W2336060235 hasConcept C502942594 @default.
• W2336060235 hasConcept C526805850 @default.
• W2336060235 hasConcept C54355233 @default.
• W2336060235 hasConcept C57074206 @default.
• W2336060235 hasConcept C71924100 @default.
• W2336060235 hasConcept C86803240 @default.
• W2336060235 hasConceptScore W2336060235C121608353 @default.

• next