Matches in SemOpenAlex for { <https://semopenalex.org/work/W2336074835> ?p ?o ?g. }
- W2336074835 abstract "The endothelium is the initial target that leads to cardiovascular disease. Knowing that the internal mammary arteries (IMA) are resistant to the development of atherosclerosis, which contrasts with coronary arteries (Cor) which are athero-prone, we hypothesize that genes over-expressed in the endothelial cells (ECs) of these two arteries will identify genes that resist atherosclerosis. Methods and Results—Microarray analysis showed 95 genes differentially expressed in the ECs of IMA vs Cor. The most statistically significant different gene was the adenosine A2B receptor. This indicates the A2B receptor may be involved in a resistance to atherosclerosis. Western blot analysis showed higher A2B expression in the IMA than in coronary arteries with or without disease from proteins harvested from these human arteries and ECs. Overexpression of A2B in ECs blunted: monocyte adhesion, cell adhesion molecule expression, migration, and the transendothelial migration of monocytes-processes directly associated with the development of atherosclerosis. Knockdown of A2B expression by siRNA promoted these processes. Conclusions—ECs derived from the IMA and Cor are distinctly different" @default.
- W2336074835 created "2016-06-24" @default.
- W2336074835 creator A5043132607 @default.
- W2336074835 date "2011-01-01" @default.
- W2336074835 modified "2023-09-27" @default.
- W2336074835 title "MOLECULAR IDENTIFICATION OF NOVEL GENES ASSOCIATED WITH ATHEROSCLEROSIS" @default.
- W2336074835 cites W132040348 @default.
- W2336074835 cites W1485550654 @default.
- W2336074835 cites W1497020854 @default.
- W2336074835 cites W1502698742 @default.
- W2336074835 cites W1507601091 @default.
- W2336074835 cites W1512161015 @default.
- W2336074835 cites W1532973457 @default.
- W2336074835 cites W1537082660 @default.
- W2336074835 cites W1552829599 @default.
- W2336074835 cites W1553107571 @default.
- W2336074835 cites W1574813722 @default.
- W2336074835 cites W1576281768 @default.
- W2336074835 cites W1578438134 @default.
- W2336074835 cites W1583614346 @default.
- W2336074835 cites W1589107965 @default.
- W2336074835 cites W159135986 @default.
- W2336074835 cites W1593931056 @default.
- W2336074835 cites W1595328686 @default.
- W2336074835 cites W1608585947 @default.
- W2336074835 cites W1727091879 @default.
- W2336074835 cites W1873449636 @default.
- W2336074835 cites W1925481732 @default.
- W2336074835 cites W1934442814 @default.
- W2336074835 cites W1934678104 @default.
- W2336074835 cites W1964310112 @default.
- W2336074835 cites W1964527977 @default.
- W2336074835 cites W1967511208 @default.
- W2336074835 cites W1969183420 @default.
- W2336074835 cites W1969969746 @default.
- W2336074835 cites W1970740293 @default.
- W2336074835 cites W1971572251 @default.
- W2336074835 cites W1971680848 @default.
- W2336074835 cites W1972946535 @default.
- W2336074835 cites W1973431843 @default.
- W2336074835 cites W1974046965 @default.
- W2336074835 cites W1974753304 @default.
- W2336074835 cites W1975043237 @default.
- W2336074835 cites W1978422523 @default.
- W2336074835 cites W1981218655 @default.
- W2336074835 cites W1982249216 @default.
- W2336074835 cites W1982872895 @default.
- W2336074835 cites W1983630074 @default.
- W2336074835 cites W1984240649 @default.
- W2336074835 cites W1984285433 @default.
- W2336074835 cites W1984320840 @default.
- W2336074835 cites W1984350319 @default.
- W2336074835 cites W1985745207 @default.
- W2336074835 cites W1986865681 @default.
- W2336074835 cites W1988852803 @default.
- W2336074835 cites W1990648591 @default.
- W2336074835 cites W1990851154 @default.
- W2336074835 cites W1993373885 @default.
- W2336074835 cites W1994476580 @default.
- W2336074835 cites W1994863757 @default.
- W2336074835 cites W1994915965 @default.
- W2336074835 cites W1995889915 @default.
- W2336074835 cites W1996790498 @default.
- W2336074835 cites W1997912679 @default.
- W2336074835 cites W1998631400 @default.
- W2336074835 cites W1999642678 @default.
- W2336074835 cites W2000494074 @default.
- W2336074835 cites W2001189110 @default.
- W2336074835 cites W2001402717 @default.
- W2336074835 cites W2003248159 @default.
- W2336074835 cites W2004462169 @default.
- W2336074835 cites W2007359045 @default.
- W2336074835 cites W2009784543 @default.
- W2336074835 cites W2012953300 @default.
- W2336074835 cites W2013169554 @default.
- W2336074835 cites W2013542441 @default.
- W2336074835 cites W2015214877 @default.
- W2336074835 cites W2017614987 @default.
- W2336074835 cites W2017623134 @default.
- W2336074835 cites W2018900385 @default.
- W2336074835 cites W2020345490 @default.
- W2336074835 cites W2022491736 @default.
- W2336074835 cites W2022717979 @default.
- W2336074835 cites W2022735247 @default.
- W2336074835 cites W2023568278 @default.
- W2336074835 cites W2024601890 @default.
- W2336074835 cites W2025054558 @default.
- W2336074835 cites W2025224418 @default.
- W2336074835 cites W2027592829 @default.
- W2336074835 cites W2027826658 @default.
- W2336074835 cites W2027923201 @default.
- W2336074835 cites W2028307216 @default.
- W2336074835 cites W2029034420 @default.
- W2336074835 cites W2029143286 @default.
- W2336074835 cites W2029314163 @default.
- W2336074835 cites W2030003945 @default.
- W2336074835 cites W2032786707 @default.
- W2336074835 cites W2035397450 @default.
- W2336074835 cites W2035907279 @default.
- W2336074835 cites W2036327238 @default.