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• W2336090438 abstract "Event Abstract Back to Event Surface topography of implants drives bone anchorage Zhen-Mei Liu1*, Robert Liddell1* and John E Davies1, 2* 1 Faculty of Dentistry, University of Toronto, Canada 2 Institute of Biomaterials and Biomedical Engineering, University of Toronto, Canada Introduction: Titanium (Ti) is widely used as a dental implant material[1]. We, and others, have shown that implant surface topography, especially at the nano-scale, plays a significant role in promoting bony healing[2],[3]. However, we have generally superimposed discrete calcium phosphate (CaP) nanocrystals (DCD), on Ti surfaces, to create a nanotopographic complexity. This begs the question; Is it the topography, or CaP chemistry that is responsible for the improved implant performance. Thus, we report here the comparative performance of nano-Ti surfaces created within the surface Ti oxide surface with those functionalized with CaP crystals, using a bone anchorage test. Materials and Methods: 380 Custom-made commercially pure titanium implants with machined surfaces were made and split into 6 groups: (A) Machined (B) A+DCD (C) A+NaOH (D) C+SBF immersion (E) C+H2O immersion (F) A+anodized. Group D was prepared to add Ca2+ ions to the complex NaOH surface. Each surface was examined by both scanning electron microscopy (SEM) and X-ray photoelectron spectroscopy (XPS). All implants were sterilized using 25kGy γ-irradiation. The implants were placed into the femora of male Wistar rats, which were sacrificed after 14, 28, 56, 98, or 140 days. The femora were harvested and then trimmed to the width of the implant, leaving the implant in between two bony arches. The force required to disrupt the model was measured with an Instron™. Data was collected and compiled using the statistical software “R”. P values <0.05 were considered significant. Results: SEM of all implant groups showed a relatively smooth surface with some micro-scale features at low magnification. At higher magnification, Group B had approximately 50% coverage of DCD, Groups C-E had a complex interconnected nanoporous structure with pore sizes up to 110 nm. Group F implants were covered with nanotubes of approximately 100nm diameter. XPS confirmed an increase in Ca on the surface of Group D (2.98%) as compared to Group C (0.66%) due to the SBF treatment. Disruption forces were seen to increase with time for all, but Groups A and B of which the disruption forces were significantly smaller than all other groups. Significant differences were found between all group pairs, with exceptions of C/F, and D/E (Figure 1) at 28 days. Discussion: At all time points, the disruption forces for Groups A and B were near zero, indicating little bony anchorage to these surfaces. On the contrary Groups C and F showed significantly increased disruption forces (C = 16.8 x B at 28 days), indicating that the Ti surface oxide nanofeatures were having a profound effect, without the addition of a CaP phase. Interestingly, when this complex oxide surface was functionalized with Ca2+ ions (Group D) the disruption force decreased: However, this was also the case in Group E, which suggested that immersion in an aqueous solution had weakened the surface oxide structure. Conclusion: Bone anchorage results from implant surface topographical complexity rather than CaP chemistry. Implants were provided by Zimmer BioMet Dental.References:[1] Y Shivata, Y Tanimoto, J Prosthodont Res 2015; 59:20.[2] JE Davies, et al Biomaterials 2014: 35:25.[3] G Mendonca, et al Biomaterials 2008; 29:3822. Keywords: Implant, Surface modification, nanotopography, surface topolography Conference: 10th World Biomaterials Congress, Montréal, Canada, 17 May - 22 May, 2016. Presentation Type: Poster Topic: Biomaterials in dental applications Citation: Liu Z, Liddell R and Davies J (2016). Surface topography of implants drives bone anchorage. Front. Bioeng. Biotechnol. Conference Abstract: 10th World Biomaterials Congress. doi: 10.3389/conf.FBIOE.2016.01.01816 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 27 Mar 2016; Published Online: 30 Mar 2016. * Correspondence: Dr. Zhen-Mei Liu, Faculty of Dentistry, University of Toronto, Toronto, ON, Canada, Email1 Dr. Robert Liddell, Faculty of Dentistry, University of Toronto, Toronto, ON, Canada, rob.liddell@mail.utoronto.ca Dr. John E Davies, Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON, Canada, davies@ecf.utoronto.ca Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Zhen-Mei Liu Robert Liddell John E Davies Google Zhen-Mei Liu Robert Liddell John E Davies Google Scholar Zhen-Mei Liu Robert Liddell John E Davies PubMed Zhen-Mei Liu Robert Liddell John E Davies Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. 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• W2336090438 title "Surface topography of implants drives bone anchorage" @default.
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