FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2336097215> ?p ?o ?g. }

• W2336097215 endingPage "74" @default.
• W2336097215 startingPage "68" @default.
• W2336097215 abstract "Background Infections are common following stroke and associated with worse outcome. Using an animal model of pneumonia, we assessed the effect of infection and its treatment on the immune response and stroke outcome. Methods Lewis rats were subjected to transient cerebral ischemia and survived for 4 weeks. One day after stroke animals were exposed to aerosolized Staphylococcus aureus, Pseudomonas aeruginosa or saline. Antibiotics (ceftiofur or enrofloxacin) were started immediately after exposure or delayed for 3 days. Behavioral tests were performed weekly. ELISPOT assays were done on lymphocytes from spleen and brain to assess autoimmune responses to myelin basic protein (MBP). Results Among animals that received immediate antibiotic therapy, infection was associated with worse outcome in ceftiofur but not enrofloxacin treated animals. (The outcome with immediate enrofloxacin therapy was so impaired that further worsening may have been difficult to detect.) A delay in antibiotic therapy was associated with better outcomes in both ceftiofur and enrofloxacin treated animals. Infection was associated with an increased likelihood of developing Th1(+) responses to MBP in non-infarcted brain (OR = 2.94 [1.07, 8.12]; P = 0.04), and Th1(+) responses to MBP in spleen and non-infarcted brain were independently associated with a decreased likelihood of stroke recovery (OR = 0.16 [0.05, 0.51; P = 0.002 and OR = 0.32 [0.12, 0.84]; P = 0.02, respectively). Conclusions Infection worsens stroke outcome in ceftiofur treated animals and increases Th1 responses to MBP. These data may help explain how infection worsens stroke outcome and suggest that treatment of infection may contribute to this outcome." @default.
• W2336097215 created "2016-06-24" @default.
• W2336097215 creator A5002204984 @default.
• W2336097215 creator A5015735448 @default.
• W2336097215 creator A5017463095 @default.
• W2336097215 creator A5018904655 @default.
• W2336097215 creator A5033220689 @default.
• W2336097215 creator A5033344867 @default.
• W2336097215 date "2016-06-01" @default.
• W2336097215 modified "2023-09-29" @default.
• W2336097215 title "The contribution of antibiotics, pneumonia and the immune response to stroke outcome" @default.
• W2336097215 cites W1775363067 @default.
• W2336097215 cites W1865953701 @default.
• W2336097215 cites W1952029789 @default.
• W2336097215 cites W1970853084 @default.
• W2336097215 cites W1972764750 @default.
• W2336097215 cites W1973372748 @default.
• W2336097215 cites W1981120565 @default.
• W2336097215 cites W1986395233 @default.
• W2336097215 cites W1987643886 @default.
• W2336097215 cites W1987887433 @default.
• W2336097215 cites W2002842060 @default.
• W2336097215 cites W2006468572 @default.
• W2336097215 cites W2006976581 @default.
• W2336097215 cites W2014598519 @default.
• W2336097215 cites W2018209237 @default.
• W2336097215 cites W2042921805 @default.
• W2336097215 cites W2074974933 @default.
• W2336097215 cites W2085287265 @default.
• W2336097215 cites W2085557552 @default.
• W2336097215 cites W2085741325 @default.
• W2336097215 cites W2086667516 @default.
• W2336097215 cites W2106329493 @default.
• W2336097215 cites W2116545273 @default.
• W2336097215 cites W2125683177 @default.
• W2336097215 cites W2140986796 @default.
• W2336097215 cites W2142132203 @default.
• W2336097215 cites W2145188688 @default.
• W2336097215 cites W2145343991 @default.
• W2336097215 cites W2145406335 @default.
• W2336097215 cites W2149474055 @default.
• W2336097215 cites W2156075560 @default.
• W2336097215 cites W2156088921 @default.
• W2336097215 cites W2162114403 @default.
• W2336097215 cites W2182541906 @default.
• W2336097215 cites W2336331566 @default.
• W2336097215 cites W2434862825 @default.
• W2336097215 cites W31589931 @default.
• W2336097215 cites W428213585 @default.
• W2336097215 cites W84639171 @default.
• W2336097215 doi "https://doi.org/10.1016/j.jneuroim.2016.04.005" @default.
• W2336097215 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4886655" @default.
• W2336097215 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27235351" @default.
• W2336097215 hasPublicationYear "2016" @default.
• W2336097215 type Work @default.
• W2336097215 sameAs 2336097215 @default.
• W2336097215 citedByCount "15" @default.
• W2336097215 countsByYear W23360972152016 @default.
• W2336097215 countsByYear W23360972152018 @default.
• W2336097215 countsByYear W23360972152019 @default.
• W2336097215 countsByYear W23360972152020 @default.
• W2336097215 countsByYear W23360972152021 @default.
• W2336097215 countsByYear W23360972152022 @default.
• W2336097215 countsByYear W23360972152023 @default.
• W2336097215 crossrefType "journal-article" @default.
• W2336097215 hasAuthorship W2336097215A5002204984 @default.
• W2336097215 hasAuthorship W2336097215A5015735448 @default.
• W2336097215 hasAuthorship W2336097215A5017463095 @default.
• W2336097215 hasAuthorship W2336097215A5018904655 @default.
• W2336097215 hasAuthorship W2336097215A5033220689 @default.
• W2336097215 hasAuthorship W2336097215A5033344867 @default.
• W2336097215 hasBestOaLocation W23360972152 @default.
• W2336097215 hasConcept C126322002 @default.
• W2336097215 hasConcept C127413603 @default.
• W2336097215 hasConcept C203014093 @default.
• W2336097215 hasConcept C2777914695 @default.
• W2336097215 hasConcept C2778512257 @default.
• W2336097215 hasConcept C2779906673 @default.
• W2336097215 hasConcept C2780122547 @default.
• W2336097215 hasConcept C2780645631 @default.
• W2336097215 hasConcept C501593827 @default.
• W2336097215 hasConcept C71924100 @default.
• W2336097215 hasConcept C78519656 @default.
• W2336097215 hasConcept C86803240 @default.
• W2336097215 hasConcept C8891405 @default.
• W2336097215 hasConcept C89423630 @default.
• W2336097215 hasConcept C94665300 @default.
• W2336097215 hasConceptScore W2336097215C126322002 @default.
• W2336097215 hasConceptScore W2336097215C127413603 @default.
• W2336097215 hasConceptScore W2336097215C203014093 @default.
• W2336097215 hasConceptScore W2336097215C2777914695 @default.
• W2336097215 hasConceptScore W2336097215C2778512257 @default.
• W2336097215 hasConceptScore W2336097215C2779906673 @default.
• W2336097215 hasConceptScore W2336097215C2780122547 @default.
• W2336097215 hasConceptScore W2336097215C2780645631 @default.
• W2336097215 hasConceptScore W2336097215C501593827 @default.
• W2336097215 hasConceptScore W2336097215C71924100 @default.
• W2336097215 hasConceptScore W2336097215C78519656 @default.

• next