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- W2336135655 abstract "A high-performance liquid chromatographic method was described for quantitating tetrandrine in rat plasma. The separation was achieved on a liquid chromatography reversed phase 5C18-AR column with a mobile phase of acetonitrile-water-diethylamine (20:80:0.1, v/v/v. pH 3.0-3.5 adjusted with perchloric acid). The detection limit was 0.03μtg/m1 for tetrandrine at a wavelength of 235 nm. The plasma concentration time profile of tetrandrine in rat was suited to a two-compartment open model at a dose of 13mg/kg, intravenously. The elimination half-life and the total body clearance of tetrandrine were 42.65 mm and 0.36 ml/mm/kg in rat." @default.
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- W2336135655 date "1997-12-01" @default.
- W2336135655 modified "2023-09-23" @default.
- W2336135655 title "Determination of Tetrandrine with High-Performance Liquid Chromatography and Its Application to Pharmacokinetic Study in Rats" @default.
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