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- W2336142983 abstract "2503 Objectives I-123 Ioflupane is a newly approved radiopharmaceutical to detect dopamine transporters in the basal ganglion to differentiate essential tremors (ET) from those of Parkinson9s disease (PD). The purpose of the study is to review initial experience and propose the optimal SPECT/CT imaging protocol using I-123 Ioflupane in neuro imaging. Methods This is a retrospective review of 38 patients who had I-123 Ioflupane imaging. The study was performed after IV injection of 5 mCi of I-123 Ioflupane. Images were acquired 4 hrs post injection on Siemens SPECT/CT system and processed with/without CT attenuation correction. Imaging parameters including CT dose, imaging field of view, target organ count activity were analyzed. Clinical data and physician impression were reviewed. Results Of 38 patients, 19 had normal dopamine terminals with maximum count activity (MCA) of 2023±579 (Mean±SD) on (L) & 2140±548 on (R). The other 19 were abnormal with decreased basal ganglion uptake of grade 1-3 dopaminergic terminal loss w/ MCA 1045±625 on (L) & 1370±585 on (R), significantly lower compared to normal patients (p Conclusions In I-123 Ioflupane imaging by SPECT/CT, lowest mAs is recommended to minimize radiation exposure. It does not affect imaging qualities. Imaging should be performed with optimized head position to include the parotid glands in the imaging field, which might provide additional information on sympatetic neuronal activity" @default.
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- W2336142983 date "2012-05-01" @default.
- W2336142983 modified "2023-09-24" @default.
- W2336142983 title "Initial experience with I-123 Ioflupane: Optimization of imaging protocol on SPECT/CT" @default.
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