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- W2336146514 startingPage "65" @default.
- W2336146514 abstract "Intrusive thinking triggers clinical symptoms in many neuropsychiatric disorders. Using drug addiction as an exemplar disorder sustained in part by intrusive thinking, we explore studies demonstrating that impairments in corticostriatal circuitry strongly contribute to intrusive thinking. Neuroimaging studies have long implicated this projection in cue-induced craving to use drugs, and preclinical models show that marked changes are produced at corticostriatal synapses in the nucleus accumbens during a relapse episode. We delineate an accumbens microcircuit that mediates cue-induced drug seeking becoming an intrusive event. This microcircuit harbors many potential therapeutic targets. We focus on preclinical and clinical studies, showing that administering N-acetylcysteine restores uptake of synaptic glutamate by astroglial glutamate transporters and thereby inhibits intrusive thinking. We posit that because intrusive thinking is a shared endophenotype in many disorders, N-acetylcysteine has positive effects in clinical trials for a variety of neuropsychiatric disorders, including drug addiction, gambling, trichotillomania, and depression." @default.
- W2336146514 created "2016-06-24" @default.
- W2336146514 creator A5006282048 @default.
- W2336146514 creator A5078035590 @default.
- W2336146514 date "2016-03-31" @default.
- W2336146514 modified "2023-10-03" @default.
- W2336146514 title "Corticostriatal circuitry in regulating diseases characterized by intrusive thinking" @default.
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