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• W2336148442 abstract "Tissues comprise multiple heterotypic cell types (e.g., epithelial, mesenchymal, and immune cells). Communication between heterotypic cell types is essential for biological cohesion and is frequently dysregulated in disease. Despite the importance of heterocellular communication, most systems biology techniques do not report cell-specific signaling data from mixtures of cells. As a result, our existing perspective of cellular behavior under-represents the influence of heterocellular signaling. Recent technical advances now permit the resolution of systems-level cell-specific signaling data. This review discusses how new physical, spatial, and isotopic resolving methods are facilitating unique systems biology studies of heterocellular communication. Tissues comprise multiple heterotypic cell types (e.g., epithelial, mesenchymal, and immune cells). Communication between heterotypic cell types is essential for biological cohesion and is frequently dysregulated in disease. Despite the importance of heterocellular communication, most systems biology techniques do not report cell-specific signaling data from mixtures of cells. As a result, our existing perspective of cellular behavior under-represents the influence of heterocellular signaling. Recent technical advances now permit the resolution of systems-level cell-specific signaling data. This review discusses how new physical, spatial, and isotopic resolving methods are facilitating unique systems biology studies of heterocellular communication. Communication between heterotypic cells is an essential component of biology and frequently deregulated in disease (e.g., cancer, neurodegenerative conditions, host–pathogen interactions). Traditional techniques cannot resolve deep cell-specific signaling information from mixed cell populations. New methods are required to measure systems-level cell-specific post-translational modifications (PTMs) in heterocellular models. Advances in physical, spatial, and isotopic cell-specific resolving technologies are enabling new heterocellular signaling experiments. Studies of heterocellular communication are revealing unique cell–cell signaling networks and will increase our understanding of metazoan biology. Communication between heterotypic cells is an essential component of biology and frequently deregulated in disease (e.g., cancer, neurodegenerative conditions, host–pathogen interactions). Traditional techniques cannot resolve deep cell-specific signaling information from mixed cell populations. New methods are required to measure systems-level cell-specific post-translational modifications (PTMs) in heterocellular models. Advances in physical, spatial, and isotopic cell-specific resolving technologies are enabling new heterocellular signaling experiments. Studies of heterocellular communication are revealing unique cell–cell signaling networks and will increase our understanding of metazoan biology. a reproducible and comprehensive method for studying phosphorylation processes. an approach to measuring cell-specific proteomes that employs nonmammalian amino acid precursor-processing enzymes to convert lysine precursors into essential L-lysine. a cytometric variant of inductively coupled plasma MS. combines tissue fixation, 21 rare-earth-labeled antibodies, and enzymatic/mechanical tissue disruption to yield stable single-cell suspensions that can be analyzed by MC. a flow cytometry technique to physically resolve fluorescently labeled cells. a population of mixed differentiated cells. a technique for resolving heterotypic cell types across multiple conditions with deep phosphoproteome coverage. enables quantitative microscope analysis of heterotypic cell models. a population of commonly differentiated cells. imaging method where fixed tissue sections are stained with rare-earth metal-conjugated antibodies and ionized by scanning laser ablation. cell contact-dependent signaling between cells (e.g., Notch–Delta). analytical method that combines the high-mass accuracy of MS with the single-cell resolution of FC. metal-ion imaging approach that allows parallelizing signaling markers with cell-lineage annotation. an experiment where multiple variables are tested concurrently. neutron-encoded amino acid labeling, which can measure a mass delta of 5–40 mDa. soluble signaling from one cell to another (e.g., growth factors). an isotopic resolution method that can provide cell type information in vivo. a custom dimensionality-reduction method with clustering used to transform raw single-cell data from MC into statistically powered 2D plots. method to isotopically differentiate the proteomes of cells grown in vitro. uses ectopic aminoacyl-tRNA synthetase/tRNA expression under lineage-specific promoters to incorporate chemically modifiable amino acid analogs at diverse sense codons. variable-specific ten-channel isobaric labeling method. a custom dimensionality-reduction method with clustering used to transform raw single-cell data from MC into statistically powered 2D plots." @default.
• W2336148442 created "2016-06-24" @default.
• W2336148442 creator A5068289205 @default.
• W2336148442 date "2016-08-01" @default.
• W2336148442 modified "2023-10-14" @default.
• W2336148442 title "Systems Biology Analysis of Heterocellular Signaling" @default.
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• W2336148442 doi "https://doi.org/10.1016/j.tibtech.2016.02.016" @default.
• W2336148442 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27087613" @default.
• W2336148442 hasPublicationYear "2016" @default.
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