FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2336162175> ?p ?o ?g. }

• W2336162175 endingPage "1290" @default.
• W2336162175 startingPage "1280" @default.
• W2336162175 abstract "BACKGROUND:Concentrated leukocytes in leukocyte- and platelet-rich plasma (L-PRP) may deliver increased levels of pro-inflammatory cytokines to activate the NF-κB signaling pathway, to counter the beneficial effects of growth factors on osteoarthritic cartilage. However, to date no relevant studies have substantiated that in vivo. MATERIAL AND METHODS:Autologous L-PRP and pure platelet-rich plasma (P-PRP) were prepared, measured for componential composition, and injected intra-articularly after 4, 5, and 6 weeks post-anterior cruciate ligament transection. Caffeic acid phenethyl ester (CAPE) was injected intraperitoneally to inhibit NF-κB activation. All rabbits were sacrificed after 8 weeks postoperative. Enzyme-linked immunosorbent assays were performed to determine interleukin 1β (IL-1β) and prostaglandin E2 (PGE2) concentrations in the synovial fluid, Indian ink staining was performed for gross morphological assessment, and hematoxylin and eosin staining and toluidine blue staining were performed for histological assessment. RESULTS:Compared with L-PRP, P-PRP injections achieved better outcomes regarding the prevention of cartilage destruction, preservation of cartilaginous matrix, and reduction of IL-1β and PGE2 concentrations. CAPE injections reversed the increased IL-1β and PGE2 concentrations in the synovial fluid after L-PRP injections and improved the outcome of L-PRP injections to a level similar to P-PRP injections, while they had no influence on the therapeutic efficacy of P-PRP injections. CONCLUSIONS:Concentrated leukocytes in L-PRP may release increased levels of pro-inflammatory cytokines to activate the NF-κB signaling pathway, to counter the beneficial effects of growth factors on osteoarthritic cartilage, and finally, result in a inferior efficacy of L-PRP to P-PRP for the treatment of osteoarthritis." @default.
• W2336162175 created "2016-06-24" @default.
• W2336162175 creator A5002582422 @default.
• W2336162175 creator A5004405695 @default.
• W2336162175 creator A5021512708 @default.
• W2336162175 creator A5039248918 @default.
• W2336162175 creator A5042299790 @default.
• W2336162175 creator A5047515709 @default.
• W2336162175 creator A5055640518 @default.
• W2336162175 date "2016-04-17" @default.
• W2336162175 modified "2023-10-17" @default.
• W2336162175 title "Advantages of Pure Platelet-Rich Plasma Compared with Leukocyte- and Platelet-Rich Plasma in Treating Rabbit Knee Osteoarthritis" @default.
• W2336162175 cites W1534012180 @default.
• W2336162175 cites W1537032233 @default.
• W2336162175 cites W1538219384 @default.
• W2336162175 cites W1983924718 @default.
• W2336162175 cites W1985859986 @default.
• W2336162175 cites W1999766372 @default.
• W2336162175 cites W2006050540 @default.
• W2336162175 cites W2009471315 @default.
• W2336162175 cites W2012535489 @default.
• W2336162175 cites W2015095938 @default.
• W2336162175 cites W2017720269 @default.
• W2336162175 cites W2021423062 @default.
• W2336162175 cites W2025803990 @default.
• W2336162175 cites W2029720037 @default.
• W2336162175 cites W2030322516 @default.
• W2336162175 cites W2031307925 @default.
• W2336162175 cites W2036305631 @default.
• W2336162175 cites W2040493554 @default.
• W2336162175 cites W2041325252 @default.
• W2336162175 cites W2046116375 @default.
• W2336162175 cites W2046563190 @default.
• W2336162175 cites W2054496091 @default.
• W2336162175 cites W2059281148 @default.
• W2336162175 cites W2060222731 @default.
• W2336162175 cites W2066581346 @default.
• W2336162175 cites W2073542861 @default.
• W2336162175 cites W2081189145 @default.
• W2336162175 cites W2094544818 @default.
• W2336162175 cites W2096005052 @default.
• W2336162175 cites W2098049472 @default.
• W2336162175 cites W2098262854 @default.
• W2336162175 cites W2099204150 @default.
• W2336162175 cites W2101102365 @default.
• W2336162175 cites W2108738802 @default.
• W2336162175 cites W2110032671 @default.
• W2336162175 cites W2115801781 @default.
• W2336162175 cites W2120938016 @default.
• W2336162175 cites W2122883560 @default.
• W2336162175 cites W2125605937 @default.
• W2336162175 cites W2132612143 @default.
• W2336162175 cites W2139270420 @default.
• W2336162175 cites W2141157018 @default.
• W2336162175 cites W2142925530 @default.
• W2336162175 cites W2148080767 @default.
• W2336162175 cites W2149781582 @default.
• W2336162175 cites W2154461664 @default.
• W2336162175 cites W2159442019 @default.
• W2336162175 cites W2163719186 @default.
• W2336162175 cites W2216912148 @default.
• W2336162175 cites W2283692228 @default.
• W2336162175 cites W2324213260 @default.
• W2336162175 cites W2342387797 @default.
• W2336162175 cites W2405106560 @default.
• W2336162175 cites W88192686 @default.
• W2336162175 doi "https://doi.org/10.12659/msm.898218" @default.
• W2336162175 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4837928" @default.
• W2336162175 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27086145" @default.
• W2336162175 hasPublicationYear "2016" @default.
• W2336162175 type Work @default.
• W2336162175 sameAs 2336162175 @default.
• W2336162175 citedByCount "47" @default.
• W2336162175 countsByYear W23361621752016 @default.
• W2336162175 countsByYear W23361621752017 @default.
• W2336162175 countsByYear W23361621752018 @default.
• W2336162175 countsByYear W23361621752019 @default.
• W2336162175 countsByYear W23361621752020 @default.
• W2336162175 countsByYear W23361621752021 @default.
• W2336162175 countsByYear W23361621752022 @default.
• W2336162175 countsByYear W23361621752023 @default.
• W2336162175 crossrefType "journal-article" @default.
• W2336162175 hasAuthorship W2336162175A5002582422 @default.
• W2336162175 hasAuthorship W2336162175A5004405695 @default.
• W2336162175 hasAuthorship W2336162175A5021512708 @default.
• W2336162175 hasAuthorship W2336162175A5039248918 @default.
• W2336162175 hasAuthorship W2336162175A5042299790 @default.
• W2336162175 hasAuthorship W2336162175A5047515709 @default.
• W2336162175 hasAuthorship W2336162175A5055640518 @default.
• W2336162175 hasBestOaLocation W23361621752 @default.
• W2336162175 hasConcept C105702510 @default.
• W2336162175 hasConcept C125473707 @default.
• W2336162175 hasConcept C126322002 @default.
• W2336162175 hasConcept C134018914 @default.
• W2336162175 hasConcept C142724271 @default.
• W2336162175 hasConcept C150903083 @default.
• W2336162175 hasConcept C164027704 @default.
• W2336162175 hasConcept C185592680 @default.

• next