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- W2336183149 abstract "This chapter reviews the major disturbances of growth and pubertal development caused by malignant disease in childhood. Growth at adolescence and normal pubertal development depend on the integrity of the pituitary–gonadal axis. Any neoplastic process that interferes with anterior pituitary function, and specifically with growth hormone secretion, thus disturbs the pattern of normal growth. The inappropriate secretion of sex steroids by gonadal tumors can also disturb normal growth and puberty. Excess cortisol and sex steroid production by tumors of the adrenal cortex can also suppress growth and lead to inappropriate virilization or feminization. Primary tumors arising in the region of the pituitary and hypothalamus constitute an important cause of abnormal growth and development. This causes endocrine disturbance resulting from direct interference with pituitary function by the tumor, causing deficiency of anterior pituitary trophic hormones or because of disturbance of the normal hypothalamic–pituitary relationship, which can produce either pituitary insufficiency or hypersecretion of anterior pituitary hormones, principally gonadotropins. The tumors of endocrine glands which affect growth and development are the malignancies of the adrenal cortex, the testis, and the ovaries. Hypopituitarism is managed by replacement of the deficient hormones." @default.
- W2336183149 created "2016-06-24" @default.
- W2336183149 creator A5045829884 @default.
- W2336183149 date "1984-01-01" @default.
- W2336183149 modified "2023-09-23" @default.
- W2336183149 title "Growth and Development" @default.
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- W2336183149 doi "https://doi.org/10.1016/b978-0-433-30277-3.50011-7" @default.
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