Matches in SemOpenAlex for { <https://semopenalex.org/work/W2336200830> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W2336200830 endingPage "366" @default.
- W2336200830 startingPage "359" @default.
- W2336200830 abstract "Digitonin solutions of labelled rhodopsin, containing 3H in the retinyl moiety, were prepared by two related methods. Labelled rhodopsin was also prepared for the first time in cetyltrimethylammonium bromide and purified by column chromatography. It was shown that only certain rhodopsin preparations on denaturation in the dark and the reduction with sodium borohydride gave up to 60% of the radioactivity in a fraction characterized as N-retinylphosphatidylethanolamine. Such preparations also gave a lipid-linked retinyl moiety at the metarhodopsin-I stage, but, as expected, a protein-linked retinyl moiety at the metarhodopsin-II stage. Other preparations however, gave exclusively protein-bound radioactivity at the native-rhodopsin, metarhodopsin-I and metarhodopsin-II stages. It is therefore conceivable that the formation of N-retinylphosphatidylethanolamine is due to a non-enzymic reaction resulting from the transfer of the retinyl moiety from its native site to an amino group of a favourably oriented phospholipid molecule. The only firmly established aspect of the rhodopsin active site remains the demonstration in our previous work that at the metarhodopsin-II stage the retinyl moiety is linked to an ∈-amino group of lysine. On the basis of chemical reactivity it is argued that the light-induced conversion of rhodopsin into metarhodopsin II involves a profound conformational change resulting in the dislocation of the retinylideneiminium chromophore from a non-polar environment in rhodopsin to a polar environment in metarhodopsin II." @default.
- W2336200830 created "2016-06-24" @default.
- W2336200830 creator A5011778713 @default.
- W2336200830 creator A5044925039 @default.
- W2336200830 date "1970-09-01" @default.
- W2336200830 modified "2023-09-26" @default.
- W2336200830 title "A convenient synthesis of labelled rhodopsin and studies on its active site" @default.
- W2336200830 cites W114793745 @default.
- W2336200830 cites W1986129405 @default.
- W2336200830 cites W1989753604 @default.
- W2336200830 cites W2042050398 @default.
- W2336200830 cites W2048971266 @default.
- W2336200830 cites W2056931256 @default.
- W2336200830 cites W2059102320 @default.
- W2336200830 cites W2060991227 @default.
- W2336200830 cites W2066299155 @default.
- W2336200830 cites W2072490592 @default.
- W2336200830 cites W2073585560 @default.
- W2336200830 cites W2084190407 @default.
- W2336200830 cites W2104782686 @default.
- W2336200830 cites W2222145397 @default.
- W2336200830 cites W2331585727 @default.
- W2336200830 cites W239911283 @default.
- W2336200830 doi "https://doi.org/10.1042/bj1190359" @default.
- W2336200830 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1179366" @default.
- W2336200830 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/5533197" @default.
- W2336200830 hasPublicationYear "1970" @default.
- W2336200830 type Work @default.
- W2336200830 sameAs 2336200830 @default.
- W2336200830 citedByCount "21" @default.
- W2336200830 crossrefType "journal-article" @default.
- W2336200830 hasAuthorship W2336200830A5011778713 @default.
- W2336200830 hasAuthorship W2336200830A5044925039 @default.
- W2336200830 hasBestOaLocation W23362008302 @default.
- W2336200830 hasConcept C185592680 @default.
- W2336200830 hasConcept C192468462 @default.
- W2336200830 hasConcept C202033177 @default.
- W2336200830 hasConcept C2776568683 @default.
- W2336200830 hasConcept C2778920010 @default.
- W2336200830 hasConcept C2780827179 @default.
- W2336200830 hasConcept C41625074 @default.
- W2336200830 hasConcept C55493867 @default.
- W2336200830 hasConcept C71240020 @default.
- W2336200830 hasConcept C75473681 @default.
- W2336200830 hasConceptScore W2336200830C185592680 @default.
- W2336200830 hasConceptScore W2336200830C192468462 @default.
- W2336200830 hasConceptScore W2336200830C202033177 @default.
- W2336200830 hasConceptScore W2336200830C2776568683 @default.
- W2336200830 hasConceptScore W2336200830C2778920010 @default.
- W2336200830 hasConceptScore W2336200830C2780827179 @default.
- W2336200830 hasConceptScore W2336200830C41625074 @default.
- W2336200830 hasConceptScore W2336200830C55493867 @default.
- W2336200830 hasConceptScore W2336200830C71240020 @default.
- W2336200830 hasConceptScore W2336200830C75473681 @default.
- W2336200830 hasIssue "3" @default.
- W2336200830 hasLocation W23362008301 @default.
- W2336200830 hasLocation W23362008302 @default.
- W2336200830 hasLocation W23362008303 @default.
- W2336200830 hasLocation W23362008304 @default.
- W2336200830 hasOpenAccess W2336200830 @default.
- W2336200830 hasPrimaryLocation W23362008301 @default.
- W2336200830 hasRelatedWork W1551957764 @default.
- W2336200830 hasRelatedWork W1982607418 @default.
- W2336200830 hasRelatedWork W1990060931 @default.
- W2336200830 hasRelatedWork W1997625228 @default.
- W2336200830 hasRelatedWork W2041441066 @default.
- W2336200830 hasRelatedWork W2046469826 @default.
- W2336200830 hasRelatedWork W2071030889 @default.
- W2336200830 hasRelatedWork W2071312289 @default.
- W2336200830 hasRelatedWork W2336200830 @default.
- W2336200830 hasRelatedWork W2951361001 @default.
- W2336200830 hasVolume "119" @default.
- W2336200830 isParatext "false" @default.
- W2336200830 isRetracted "false" @default.
- W2336200830 magId "2336200830" @default.
- W2336200830 workType "article" @default.