Matches in SemOpenAlex for { <https://semopenalex.org/work/W2336224332> ?p ?o ?g. }
- W2336224332 abstract "Mathematical modeling of the cardiovascular system is useful in quantifying system-level responses to external and internal perturbations, which are challenging to achieve in clinical studies. Most existing cardiovascular models are closed-loop systems and do not take into account the fluid and electrolyte exchanges and the body-fluid homeostasis. We propose a new system-level simulation model that modifies and couples an open-source cardiovascular model with a renal system model. The new model has the capability to simulate both the short- and long-term responses of the cardiovascular system and the body-fluid homeostasis due to changes in the amount of fluid intake. In the present study, we apply the model to investigate the short- and long-term changes in the human cardiovascular and renal systems, in responses to excessive fluid intake. For the short-term simulations, an instant but mild increase in mean arterial pressure is found, while the heart rate decreases slightly, after an ingestion of 500 mL of water. The results agree reasonably well with data from clinical studies. Simulation results also show that a prolonged elevation of daily fluid intake leads to chronic adaptations of system parameters, such as the blood pressure and hormonal levels. These adaptations cause an increase in the left ventricular stroke work during each cardiac cycle, which may have implications on the chronic remodeling of the myocardial structures and its mechanical functions. These chronic overload remodeling may eventually lead to pathological cardiovascular conditions, such as cardiac arrhythmias and congestive heart failure." @default.
- W2336224332 created "2016-06-24" @default.
- W2336224332 creator A5004526929 @default.
- W2336224332 creator A5009904071 @default.
- W2336224332 creator A5060858086 @default.
- W2336224332 date "2016-01-01" @default.
- W2336224332 modified "2023-09-28" @default.
- W2336224332 title "Effects of Excessive Water Intake on Body-Fluid Homeostasis and the Cardiovascular System — A Computer Simulation" @default.
- W2336224332 cites W1499222776 @default.
- W2336224332 cites W1603267641 @default.
- W2336224332 cites W1894092760 @default.
- W2336224332 cites W1964723617 @default.
- W2336224332 cites W1975508939 @default.
- W2336224332 cites W1975633537 @default.
- W2336224332 cites W1979341804 @default.
- W2336224332 cites W1981078175 @default.
- W2336224332 cites W2007508296 @default.
- W2336224332 cites W2007642910 @default.
- W2336224332 cites W2012638983 @default.
- W2336224332 cites W2015898306 @default.
- W2336224332 cites W2019476654 @default.
- W2336224332 cites W2019606292 @default.
- W2336224332 cites W2028075478 @default.
- W2336224332 cites W2042443829 @default.
- W2336224332 cites W2049402988 @default.
- W2336224332 cites W2052230379 @default.
- W2336224332 cites W2059882879 @default.
- W2336224332 cites W2062633545 @default.
- W2336224332 cites W2068340069 @default.
- W2336224332 cites W2070130929 @default.
- W2336224332 cites W2073982294 @default.
- W2336224332 cites W2106031890 @default.
- W2336224332 cites W2106589350 @default.
- W2336224332 cites W2109738640 @default.
- W2336224332 cites W2112149509 @default.
- W2336224332 cites W2126078270 @default.
- W2336224332 cites W2129695314 @default.
- W2336224332 cites W2152199055 @default.
- W2336224332 cites W2155422453 @default.
- W2336224332 cites W2167986797 @default.
- W2336224332 cites W2168412919 @default.
- W2336224332 cites W2321007701 @default.
- W2336224332 cites W2321673365 @default.
- W2336224332 cites W2327202500 @default.
- W2336224332 cites W2518538812 @default.
- W2336224332 cites W3148998837 @default.
- W2336224332 doi "https://doi.org/10.1016/b978-0-12-804203-8.00010-9" @default.
- W2336224332 hasPublicationYear "2016" @default.
- W2336224332 type Work @default.
- W2336224332 sameAs 2336224332 @default.
- W2336224332 citedByCount "1" @default.
- W2336224332 countsByYear W23362243322023 @default.
- W2336224332 crossrefType "book-chapter" @default.
- W2336224332 hasAuthorship W2336224332A5004526929 @default.
- W2336224332 hasAuthorship W2336224332A5009904071 @default.
- W2336224332 hasAuthorship W2336224332A5060858086 @default.
- W2336224332 hasConcept C126322002 @default.
- W2336224332 hasConcept C139940330 @default.
- W2336224332 hasConcept C164705383 @default.
- W2336224332 hasConcept C2776735168 @default.
- W2336224332 hasConcept C2778198053 @default.
- W2336224332 hasConcept C3017845882 @default.
- W2336224332 hasConcept C63645605 @default.
- W2336224332 hasConcept C71315377 @default.
- W2336224332 hasConcept C71924100 @default.
- W2336224332 hasConcept C84393581 @default.
- W2336224332 hasConceptScore W2336224332C126322002 @default.
- W2336224332 hasConceptScore W2336224332C139940330 @default.
- W2336224332 hasConceptScore W2336224332C164705383 @default.
- W2336224332 hasConceptScore W2336224332C2776735168 @default.
- W2336224332 hasConceptScore W2336224332C2778198053 @default.
- W2336224332 hasConceptScore W2336224332C3017845882 @default.
- W2336224332 hasConceptScore W2336224332C63645605 @default.
- W2336224332 hasConceptScore W2336224332C71315377 @default.
- W2336224332 hasConceptScore W2336224332C71924100 @default.
- W2336224332 hasConceptScore W2336224332C84393581 @default.
- W2336224332 hasLocation W23362243321 @default.
- W2336224332 hasOpenAccess W2336224332 @default.
- W2336224332 hasPrimaryLocation W23362243321 @default.
- W2336224332 hasRelatedWork W12604848 @default.
- W2336224332 hasRelatedWork W180645615 @default.
- W2336224332 hasRelatedWork W191014753 @default.
- W2336224332 hasRelatedWork W1975130797 @default.
- W2336224332 hasRelatedWork W2144545074 @default.
- W2336224332 hasRelatedWork W2233633567 @default.
- W2336224332 hasRelatedWork W2246156513 @default.
- W2336224332 hasRelatedWork W2268919114 @default.
- W2336224332 hasRelatedWork W2269046781 @default.
- W2336224332 hasRelatedWork W2337800065 @default.
- W2336224332 hasRelatedWork W2398670482 @default.
- W2336224332 hasRelatedWork W2405303023 @default.
- W2336224332 hasRelatedWork W2421712347 @default.
- W2336224332 hasRelatedWork W2587266823 @default.
- W2336224332 hasRelatedWork W2899262621 @default.
- W2336224332 hasRelatedWork W2924301167 @default.
- W2336224332 hasRelatedWork W3055690057 @default.
- W2336224332 hasRelatedWork W3202588990 @default.
- W2336224332 hasRelatedWork W3208293479 @default.
- W2336224332 isParatext "false" @default.
- W2336224332 isRetracted "false" @default.