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- W2336241519 endingPage "119" @default.
- W2336241519 startingPage "104" @default.
- W2336241519 abstract "Magnetic nanoparticles (MNPs) have been used in many diagnostic and therapeutic biomedical applications over the past few decades to enhance imaging contrast, steer drugs to targets, and treat tumors via hyperthermia. Optical coherence tomography (OCT) is an optical biomedical imaging modality that relies on the detection of backscattered light to generate high-resolution cross-sectional images of biological tissue. MNPs have been utilized as imaging contrast and perturbative mechanical agents in OCT in techniques called magnetomotive OCT (MM-OCT) and magnetomotive elastography (MM-OCE), respectively. MNPs have also been independently used for magnetic hyperthermia treatments, enabling therapeutic functions such as killing tumor cells. It is well known that the localized tissue heating during hyperthermia treatments result in a change in the biomechanical properties of the tissue. Therefore, we propose a novel dosimetric technique for hyperthermia treatment based on the viscoelasticity change detected by MM-OCE, further enabling the theranostic function of MNPs. In this paper, we first review the basic principles and applications of MM-OCT, MM-OCE, and magnetic hyperthermia, and present new preliminary results supporting the concept of MM-OCE-based hyperthermia dosimetry." @default.
- W2336241519 created "2016-06-24" @default.
- W2336241519 creator A5006340080 @default.
- W2336241519 creator A5020121219 @default.
- W2336241519 creator A5025658455 @default.
- W2336241519 creator A5026404072 @default.
- W2336241519 creator A5034155657 @default.
- W2336241519 creator A5058617463 @default.
- W2336241519 creator A5072385874 @default.
- W2336241519 date "2016-07-01" @default.
- W2336241519 modified "2023-09-23" @default.
- W2336241519 title "Magnetomotive Optical Coherence Elastography for Magnetic Hyperthermia Dosimetry Based on Dynamic Tissue Biomechanics" @default.
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