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- W2336282365 abstract "Reductions in serum proteins, similar to those seen in patients, were produced in rats treated with 1000 IU/kg/day of L-asparaginase. In particular, plasma albumin and γ-globulin were significantly decreased. L-Asparaginase treatment was examined for its effects on hepatic microsomal drug metabolism and on the inductive effects of phenobarbital. L-Asparaginase did not significantly alter the basal activities of aniline hydroxylase, ethylmorphine N-demethylase, or p-nitrobenzoic acid nitroreductase. Furthermore, the inductive effect of phenobarbital on these enzymes was not altered, which suggests that some proteins turning over at a relatively rapid rate are not altered by L-asparaginase treatment. The experimental design used is presented in a format which may be of general applicability in the early assessment of interactions that may occur with drug combinations to be used in cancer chemotherapy." @default.
- W2336282365 created "2016-06-24" @default.
- W2336282365 date "1970-10-01" @default.
- W2336282365 modified "2023-09-26" @default.
- W2336282365 title "Studies of Hepatic Microsomal Enzymes, Serum Proteins, and Serum Cholesterol After Treatment of Rats With <sc>L</sc>-Asparaginase Alone or in Combination With Phenobarbital<xref ref-type=fn rid=FN2>2</xref>" @default.
- W2336282365 doi "https://doi.org/10.1093/jnci/45.4.783" @default.
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