Matches in SemOpenAlex for { <https://semopenalex.org/work/W2336352013> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W2336352013 abstract "Event Abstract Back to Event Development of self-deployment and drug release polymeric film device Taro Kondo1*, Zhaleh K. Nezhad2*, Lijuin Chen1*, Jin Suzuki1*, Nobuhiro Nagai2*, Matsuhiko Nishizawa1, Toshiaki Abe2* and Hirokazu Kaji1* 1 Tohoku University, Bioengineering and Robotics, Japan 2 Tohoku University, Clinical Cell Therapy, Japan Introduction: The design of drug-delivery systems (DDS) targeting a local specific organ in body, e.g., bladder and subretinal structure, is one of the most challenging tasks. It is ideal for DDS devices to be less-invasive as much as possible. Given the conventional DDS devices, DDS microspheres are superior in terms of less-invasive by injection but they cannot be located at the affected area. On the other hand, sheet type DDS devices require surgical procedure to retain in the body while they can delivery drug for long-term at affected area. Therefore we aimed at developing of DDS device that can be injected and located at the affected area for long-term drug release. We made the DDS devices by embedding DDS microspheres in polymeric film. Herein, we report the fabrication of device, microspheres distribution in the film, release characteristics and self-deployment. Material and Method: Collagen microspheres (COLs) were made by water-in-oil emulsion method[1]. And COLs were immersed in solution of a model drug FITC-dextran (FD-40). The devices were made by photopolymerization with UV light of mixtures of polyethylene glycol dimethacrylate (PEGDM), a photopolymerization initiator and COLs (Fig.1). The devices were observed by SEM and fluorescence microscope to reveal the distribution of COLs in PEGDM. In vitro release study was carried out to reveal release characteristics. To estimate the amounts of FD-40 that had diffused out of the devices, the devices were immersed in 3 mL of PBS and incubated at 37 C. The fluorescent intensities of the PBS solutions were measured spectrofluorometrically. PEGDM sheets of different thickness were photopolymerized with UV light. They were rounded several times around a glass cylindrical shape and the deployment times were measured in water in order to examine self-deployment characteristics. Result and Discussion: COLs were uniformly distributed in the device (Fig.2) and a part of COLs was exposed on the surface of the device. In vitro release study confirmed that devices could release FD-40 continuously over 10 days. Additionally, release characteristics changed matrix type by increasing the concentration of COLs in the device. PEGDM sheets showed a linear relationship between deployment time and the number of turns of the sheet until it is fully expanded. These observations and Fig. 3 indicate the injectability of this device. Conclusion: We developed a new DDS device targeting a local specific organ, which can be injected and release drugs over 10 days. This device can provide less-invasive and long-term locally drug release. Embedding DDS microspheres in thin film has great promise to efficacious treatment. Fig. 1: The DDS device (22 mm × 22 mm × 0.05 mm ) containing 500 mg/mL COLs Fig. 2: Fluorescence image of device containing 500 mg/mL COLs shows uniform COLs distribution. Fig. 3: The injection of the device containing 500 mg/mL COLs by stainless needle References:[1] N. Nagai, N. Kumasaka, T. Kawashima, H. Kaji, M. Nishizawa and T. Abe, Preparation and characterization of collagen microspheres for sustained release of VEGF, Journal of Materials Science Materials in Medicine, 21, 1891-1898(2010). Keywords: Drug delivery, medical application Conference: 10th World Biomaterials Congress, Montréal, Canada, 17 May - 22 May, 2016. Presentation Type: Poster Topic: Biomaterials for therapeutic delivery Citation: Kondo T, Nezhad ZK, Chen L, Suzuki J, Nagai N, Nishizawa M, Abe T and Kaji H (2016). Development of self-deployment and drug release polymeric film device. Front. Bioeng. Biotechnol. Conference Abstract: 10th World Biomaterials Congress. doi: 10.3389/conf.FBIOE.2016.01.01857 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 27 Mar 2016; Published Online: 30 Mar 2016. * Correspondence: Dr. Taro Kondo, Tohoku University, Bioengineering and Robotics, Sendai, Japan, Email1 Dr. Zhaleh K Nezhad, Tohoku University, Clinical Cell Therapy, Sendai, Japan, Email2 Dr. Lijuin Chen, Tohoku University, Bioengineering and Robotics, Sendai, Japan, Email3 Dr. Jin Suzuki, Tohoku University, Bioengineering and Robotics, Sendai, Japan, Email4 Dr. Nobuhiro Nagai, Tohoku University, Clinical Cell Therapy, Sendai, Japan, Email5 Dr. Toshiaki Abe, Tohoku University, Clinical Cell Therapy, Sendai, Japan, Email6 Dr. Hirokazu Kaji, Tohoku University, Bioengineering and Robotics, Sendai, Japan, Email7 Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Taro Kondo Zhaleh K Nezhad Lijuin Chen Jin Suzuki Nobuhiro Nagai Matsuhiko Nishizawa Toshiaki Abe Hirokazu Kaji Google Taro Kondo Zhaleh K Nezhad Lijuin Chen Jin Suzuki Nobuhiro Nagai Matsuhiko Nishizawa Toshiaki Abe Hirokazu Kaji Google Scholar Taro Kondo Zhaleh K Nezhad Lijuin Chen Jin Suzuki Nobuhiro Nagai Matsuhiko Nishizawa Toshiaki Abe Hirokazu Kaji PubMed Taro Kondo Zhaleh K Nezhad Lijuin Chen Jin Suzuki Nobuhiro Nagai Matsuhiko Nishizawa Toshiaki Abe Hirokazu Kaji Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page." @default.
- W2336352013 created "2016-06-24" @default.
- W2336352013 creator A5006256143 @default.
- W2336352013 creator A5034173900 @default.
- W2336352013 creator A5034326904 @default.
- W2336352013 creator A5036029495 @default.
- W2336352013 creator A5037599427 @default.
- W2336352013 creator A5040220342 @default.
- W2336352013 creator A5062619476 @default.
- W2336352013 creator A5076040532 @default.
- W2336352013 date "2016-01-01" @default.
- W2336352013 modified "2023-10-18" @default.
- W2336352013 title "Development of self-deployment and drug release polymeric film device" @default.
- W2336352013 doi "https://doi.org/10.3389/conf.fbioe.2016.01.01857" @default.
- W2336352013 hasPublicationYear "2016" @default.
- W2336352013 type Work @default.
- W2336352013 sameAs 2336352013 @default.
- W2336352013 citedByCount "0" @default.
- W2336352013 crossrefType "journal-article" @default.
- W2336352013 hasAuthorship W2336352013A5006256143 @default.
- W2336352013 hasAuthorship W2336352013A5034173900 @default.
- W2336352013 hasAuthorship W2336352013A5034326904 @default.
- W2336352013 hasAuthorship W2336352013A5036029495 @default.
- W2336352013 hasAuthorship W2336352013A5037599427 @default.
- W2336352013 hasAuthorship W2336352013A5040220342 @default.
- W2336352013 hasAuthorship W2336352013A5062619476 @default.
- W2336352013 hasAuthorship W2336352013A5076040532 @default.
- W2336352013 hasBestOaLocation W23363520131 @default.
- W2336352013 hasConcept C127413603 @default.
- W2336352013 hasConcept C136229726 @default.
- W2336352013 hasConcept C15487406 @default.
- W2336352013 hasConcept C159985019 @default.
- W2336352013 hasConcept C171250308 @default.
- W2336352013 hasConcept C189942447 @default.
- W2336352013 hasConcept C192562407 @default.
- W2336352013 hasConcept C2776964284 @default.
- W2336352013 hasConcept C2779820397 @default.
- W2336352013 hasConcept C41008148 @default.
- W2336352013 hasConcept C42360764 @default.
- W2336352013 hasConcept C44228677 @default.
- W2336352013 hasConcept C521977710 @default.
- W2336352013 hasConcept C71924100 @default.
- W2336352013 hasConceptScore W2336352013C127413603 @default.
- W2336352013 hasConceptScore W2336352013C136229726 @default.
- W2336352013 hasConceptScore W2336352013C15487406 @default.
- W2336352013 hasConceptScore W2336352013C159985019 @default.
- W2336352013 hasConceptScore W2336352013C171250308 @default.
- W2336352013 hasConceptScore W2336352013C189942447 @default.
- W2336352013 hasConceptScore W2336352013C192562407 @default.
- W2336352013 hasConceptScore W2336352013C2776964284 @default.
- W2336352013 hasConceptScore W2336352013C2779820397 @default.
- W2336352013 hasConceptScore W2336352013C41008148 @default.
- W2336352013 hasConceptScore W2336352013C42360764 @default.
- W2336352013 hasConceptScore W2336352013C44228677 @default.
- W2336352013 hasConceptScore W2336352013C521977710 @default.
- W2336352013 hasConceptScore W2336352013C71924100 @default.
- W2336352013 hasLocation W23363520131 @default.
- W2336352013 hasOpenAccess W2336352013 @default.
- W2336352013 hasPrimaryLocation W23363520131 @default.
- W2336352013 hasRelatedWork W1944200023 @default.
- W2336352013 hasRelatedWork W2047702264 @default.
- W2336352013 hasRelatedWork W2129508022 @default.
- W2336352013 hasRelatedWork W2142512217 @default.
- W2336352013 hasRelatedWork W2279810780 @default.
- W2336352013 hasRelatedWork W2343018661 @default.
- W2336352013 hasRelatedWork W2602647652 @default.
- W2336352013 hasRelatedWork W3160019508 @default.
- W2336352013 hasRelatedWork W3163350643 @default.
- W2336352013 hasRelatedWork W3190538570 @default.
- W2336352013 hasVolume "4" @default.
- W2336352013 isParatext "false" @default.
- W2336352013 isRetracted "false" @default.
- W2336352013 magId "2336352013" @default.
- W2336352013 workType "article" @default.