Matches in SemOpenAlex for { <https://semopenalex.org/work/W2336423970> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2336423970 abstract "The search for new antimalarial drugs has become increasingly urgent due to plasmodial resistance to existing drugs. As part of this global effort, the present study aimed at evaluating the antimalarial activity of two traditionally used medicinal plants against the disease. Acute toxicity and four-day suppressive effects of aqueous, methanol and chloroform extracts of the seed and leaf of Brucea antidysenterica and Ocimum lamiifolium, respectively, were investigated in Swiss albino mice using Plasmodium berghei using standard procedures. Methanol extract of the leaves of O. lamiifolium did not exhibit any sign of acute toxicity up to the dose of 2000 mg/kg body weight. However, all mice provided with seeds of B. antidesenterica at a dose of 2000 mg/kg body died within 24 h. The aqueous, methanol and chloroform crude extracts of B. antidesenterica significantly (p < 0.05) inhibited parasitaemia in a dose-dependent manner and prevented body weight loss at doses of 200, 400 and 600 mg/kg body weight. In addition, the extracts prolonged the mean survival time of P. berghei-infected mice compared to the non-treated control. However, it did not prevent reduction in packed cell volume except the chloroform extract in three doses and methanol extract at 200 mg/kg and 400 mg/kg. Extracts from O. lamiifolium also exhibited significant (p < 0.05) antiplasmodial activities. The extracts did not prevent body weight loss and PCV reduction, especially in chloroform. The highest suppression was recorded from aqueous crude extract of O. lamiifolium with 35.53 % in the dose of 600 mg/kg. On the other hand, a similar higher suppression was found in both methanol and chloroform of crude extracts of B. antidesenterica with 47.70 %, 46.44 % of chemosuppression, respectively, in its highest dose tested. Crude aqueous, methanol and chloroform extracts of the two medicinal plants possess acceptable antimalarial effects. However, further investigation should be pursued on toxicity study and to isolate the bioactive components responsible for the observed antimalarial action of the plants." @default.
- W2336423970 created "2016-06-24" @default.
- W2336423970 creator A5006433841 @default.
- W2336423970 creator A5031370308 @default.
- W2336423970 creator A5044602450 @default.
- W2336423970 creator A5083438167 @default.
- W2336423970 date "2016-04-14" @default.
- W2336423970 modified "2023-09-24" @default.
- W2336423970 title "Antimalarial properties of crude extracts of seeds of Brucea antidysenterica and leaves of Ocimum lamiifolium" @default.
- W2336423970 cites W1983298881 @default.
- W2336423970 cites W2033634323 @default.
- W2336423970 cites W2054869457 @default.
- W2336423970 cites W2071988518 @default.
- W2336423970 cites W2075786289 @default.
- W2336423970 cites W2078036850 @default.
- W2336423970 cites W2108209076 @default.
- W2336423970 cites W2145159657 @default.
- W2336423970 cites W2162133004 @default.
- W2336423970 cites W2162552677 @default.
- W2336423970 cites W2165109240 @default.
- W2336423970 cites W2171102256 @default.
- W2336423970 cites W2171529384 @default.
- W2336423970 cites W2242283594 @default.
- W2336423970 cites W4233817843 @default.
- W2336423970 doi "https://doi.org/10.1186/s12906-016-1098-9" @default.
- W2336423970 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4831165" @default.
- W2336423970 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27075995" @default.
- W2336423970 hasPublicationYear "2016" @default.
- W2336423970 type Work @default.
- W2336423970 sameAs 2336423970 @default.
- W2336423970 citedByCount "28" @default.
- W2336423970 countsByYear W23364239702016 @default.
- W2336423970 countsByYear W23364239702018 @default.
- W2336423970 countsByYear W23364239702019 @default.
- W2336423970 countsByYear W23364239702020 @default.
- W2336423970 countsByYear W23364239702021 @default.
- W2336423970 countsByYear W23364239702022 @default.
- W2336423970 countsByYear W23364239702023 @default.
- W2336423970 crossrefType "journal-article" @default.
- W2336423970 hasAuthorship W2336423970A5006433841 @default.
- W2336423970 hasAuthorship W2336423970A5031370308 @default.
- W2336423970 hasAuthorship W2336423970A5044602450 @default.
- W2336423970 hasAuthorship W2336423970A5083438167 @default.
- W2336423970 hasBestOaLocation W23364239701 @default.
- W2336423970 hasConcept C116263406 @default.
- W2336423970 hasConcept C126322002 @default.
- W2336423970 hasConcept C167552308 @default.
- W2336423970 hasConcept C185592680 @default.
- W2336423970 hasConcept C203014093 @default.
- W2336423970 hasConcept C2777237215 @default.
- W2336423970 hasConcept C2778048844 @default.
- W2336423970 hasConcept C2779158651 @default.
- W2336423970 hasConcept C2779342943 @default.
- W2336423970 hasConcept C2781144210 @default.
- W2336423970 hasConcept C29730261 @default.
- W2336423970 hasConcept C43617362 @default.
- W2336423970 hasConcept C556039675 @default.
- W2336423970 hasConcept C71924100 @default.
- W2336423970 hasConcept C98274493 @default.
- W2336423970 hasConceptScore W2336423970C116263406 @default.
- W2336423970 hasConceptScore W2336423970C126322002 @default.
- W2336423970 hasConceptScore W2336423970C167552308 @default.
- W2336423970 hasConceptScore W2336423970C185592680 @default.
- W2336423970 hasConceptScore W2336423970C203014093 @default.
- W2336423970 hasConceptScore W2336423970C2777237215 @default.
- W2336423970 hasConceptScore W2336423970C2778048844 @default.
- W2336423970 hasConceptScore W2336423970C2779158651 @default.
- W2336423970 hasConceptScore W2336423970C2779342943 @default.
- W2336423970 hasConceptScore W2336423970C2781144210 @default.
- W2336423970 hasConceptScore W2336423970C29730261 @default.
- W2336423970 hasConceptScore W2336423970C43617362 @default.
- W2336423970 hasConceptScore W2336423970C556039675 @default.
- W2336423970 hasConceptScore W2336423970C71924100 @default.
- W2336423970 hasConceptScore W2336423970C98274493 @default.
- W2336423970 hasFunder F4320324791 @default.
- W2336423970 hasIssue "1" @default.
- W2336423970 hasLocation W23364239701 @default.
- W2336423970 hasLocation W23364239702 @default.
- W2336423970 hasLocation W23364239703 @default.
- W2336423970 hasLocation W23364239704 @default.
- W2336423970 hasOpenAccess W2336423970 @default.
- W2336423970 hasPrimaryLocation W23364239701 @default.
- W2336423970 hasRelatedWork W1766723988 @default.
- W2336423970 hasRelatedWork W2034293733 @default.
- W2336423970 hasRelatedWork W2078777836 @default.
- W2336423970 hasRelatedWork W2548670525 @default.
- W2336423970 hasRelatedWork W2918010035 @default.
- W2336423970 hasRelatedWork W3005656987 @default.
- W2336423970 hasRelatedWork W3087591478 @default.
- W2336423970 hasRelatedWork W4211054376 @default.
- W2336423970 hasRelatedWork W4384929160 @default.
- W2336423970 hasRelatedWork W2727929473 @default.
- W2336423970 hasVolume "16" @default.
- W2336423970 isParatext "false" @default.
- W2336423970 isRetracted "false" @default.
- W2336423970 magId "2336423970" @default.
- W2336423970 workType "article" @default.