FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2336450853> ?p ?o ?g. }

• W2336450853 endingPage "1090" @default.
• W2336450853 startingPage "1082" @default.
• W2336450853 abstract "AIM: To investigate the therapeutic effects and related mechanisms of two new cannabis preparations,O-1602 and cannabidiol(CBD),on lipopolysaccharide(LPS)-induced rodent models of intestinal motility disorder in vivo and in vitro.METHODS: The animal model of intestinal motility disorder was induced by intraperitoneal injection of LPS in mice.The gastrointestinal transit was measured by gavaging charcoal marker.Western blotting was applied to evaluate the protein expression of G-protein-coupled receptor 55(GPR55).Meanwhile,the levels of tumor necrosis factor α(TNF-α) and interleukin 6(IL-6) were tested by ELISA to assess the inflammatory degree.Smooth muscle strips from the rat and mouse ileum were incubated with LPS in vitro to establish motility disorder,and both the spontaneous contraction and electrically-evoked contraction were recorded using the organ bath technique.The traditional intracellular microelectrode technique was used to record the changes of membrane potential of smooth muscle cells.The method of determining phosphorus content was applied to assay the Ca2+-ATPase activity in smooth muscle tissues.RESULTS: In vivo,LPS resulted in significant inflammation and the disorder of gut movement(P0.01).Pretreatment with CBD decreased both the level of IL-6(P0.01) and the expression of GPR55(P0.01),and further improved the motility of gut movement(P0.05).O-1602 and CBD selectively normalized LPS-induced spontaneous and electrically-evoked contraction disorder of intestinal smooth muscle strips of rats and mice in vitro(P0.05 or P0.01),but they had no effect on the membrane potential of the smooth muscle cells both in normal and pathophysiological states.CBD also decreased the elevated Ca2+-ATPase activity in smooth muscle tissues induced by LPS(P0.05).CONCLUSION: In vivo,CBD shows protective effect on LPS-induced intestinal motility disorder by reducing inflammation and down-regulating GPR55 expression.O-1602 and CBD counterbalance LPS-induced intestinal motility disorder to some extent in vitro,and the possible mechanism may be involved in regulating the Ca2+-ATPase activity of smooth muscle tissues,but not including the change of membrane potential." @default.
• W2336450853 created "2016-06-24" @default.
• W2336450853 creator A5045130424 @default.
• W2336450853 creator A5045393458 @default.
• W2336450853 creator A5048038908 @default.
• W2336450853 creator A5049979929 @default.
• W2336450853 creator A5052486359 @default.
• W2336450853 creator A5075941812 @default.
• W2336450853 creator A5076120955 @default.
• W2336450853 creator A5087261074 @default.
• W2336450853 date "2012-01-01" @default.
• W2336450853 modified "2023-09-27" @default.
• W2336450853 title "Effects of new cannabis preparations O-1602 and cannabidiol on LPS-induced intestinal motility disorder in rodents" @default.
• W2336450853 hasPublicationYear "2012" @default.
• W2336450853 type Work @default.
• W2336450853 sameAs 2336450853 @default.
• W2336450853 citedByCount "0" @default.
• W2336450853 crossrefType "journal-article" @default.
• W2336450853 hasAuthorship W2336450853A5045130424 @default.
• W2336450853 hasAuthorship W2336450853A5045393458 @default.
• W2336450853 hasAuthorship W2336450853A5048038908 @default.
• W2336450853 hasAuthorship W2336450853A5049979929 @default.
• W2336450853 hasAuthorship W2336450853A5052486359 @default.
• W2336450853 hasAuthorship W2336450853A5075941812 @default.
• W2336450853 hasAuthorship W2336450853A5076120955 @default.
• W2336450853 hasAuthorship W2336450853A5087261074 @default.
• W2336450853 hasConcept C104317684 @default.
• W2336450853 hasConcept C118552586 @default.
• W2336450853 hasConcept C126322002 @default.
• W2336450853 hasConcept C134018914 @default.
• W2336450853 hasConcept C150903083 @default.
• W2336450853 hasConcept C163415756 @default.
• W2336450853 hasConcept C17991360 @default.
• W2336450853 hasConcept C185592680 @default.
• W2336450853 hasConcept C207001950 @default.
• W2336450853 hasConcept C2776895053 @default.
• W2336450853 hasConcept C2777056318 @default.
• W2336450853 hasConcept C2777226302 @default.
• W2336450853 hasConcept C2778754761 @default.
• W2336450853 hasConcept C2780159080 @default.
• W2336450853 hasConcept C55493867 @default.
• W2336450853 hasConcept C58207958 @default.
• W2336450853 hasConcept C71924100 @default.
• W2336450853 hasConcept C85265743 @default.
• W2336450853 hasConcept C86803240 @default.
• W2336450853 hasConcept C95444343 @default.
• W2336450853 hasConcept C98274493 @default.
• W2336450853 hasConceptScore W2336450853C104317684 @default.
• W2336450853 hasConceptScore W2336450853C118552586 @default.
• W2336450853 hasConceptScore W2336450853C126322002 @default.
• W2336450853 hasConceptScore W2336450853C134018914 @default.
• W2336450853 hasConceptScore W2336450853C150903083 @default.
• W2336450853 hasConceptScore W2336450853C163415756 @default.
• W2336450853 hasConceptScore W2336450853C17991360 @default.
• W2336450853 hasConceptScore W2336450853C185592680 @default.
• W2336450853 hasConceptScore W2336450853C207001950 @default.
• W2336450853 hasConceptScore W2336450853C2776895053 @default.
• W2336450853 hasConceptScore W2336450853C2777056318 @default.
• W2336450853 hasConceptScore W2336450853C2777226302 @default.
• W2336450853 hasConceptScore W2336450853C2778754761 @default.
• W2336450853 hasConceptScore W2336450853C2780159080 @default.
• W2336450853 hasConceptScore W2336450853C55493867 @default.
• W2336450853 hasConceptScore W2336450853C58207958 @default.
• W2336450853 hasConceptScore W2336450853C71924100 @default.
• W2336450853 hasConceptScore W2336450853C85265743 @default.
• W2336450853 hasConceptScore W2336450853C86803240 @default.
• W2336450853 hasConceptScore W2336450853C95444343 @default.
• W2336450853 hasConceptScore W2336450853C98274493 @default.
• W2336450853 hasIssue "6" @default.
• W2336450853 hasLocation W23364508531 @default.
• W2336450853 hasOpenAccess W2336450853 @default.
• W2336450853 hasPrimaryLocation W23364508531 @default.
• W2336450853 hasRelatedWork W1967870569 @default.
• W2336450853 hasRelatedWork W1997585015 @default.
• W2336450853 hasRelatedWork W2002723577 @default.
• W2336450853 hasRelatedWork W2010154677 @default.
• W2336450853 hasRelatedWork W2014765692 @default.
• W2336450853 hasRelatedWork W2030171924 @default.
• W2336450853 hasRelatedWork W2035553508 @default.
• W2336450853 hasRelatedWork W2045535181 @default.
• W2336450853 hasRelatedWork W2059141707 @default.
• W2336450853 hasRelatedWork W2063607987 @default.
• W2336450853 hasRelatedWork W2071956075 @default.
• W2336450853 hasRelatedWork W2084280316 @default.
• W2336450853 hasRelatedWork W2105928569 @default.
• W2336450853 hasRelatedWork W2155134319 @default.
• W2336450853 hasRelatedWork W2314245962 @default.
• W2336450853 hasRelatedWork W2373370485 @default.
• W2336450853 hasRelatedWork W2726481326 @default.
• W2336450853 hasRelatedWork W2913793152 @default.
• W2336450853 hasRelatedWork W2918094886 @default.
• W2336450853 hasRelatedWork W3087190052 @default.
• W2336450853 hasVolume "28" @default.
• W2336450853 isParatext "false" @default.
• W2336450853 isRetracted "false" @default.
• W2336450853 magId "2336450853" @default.
• W2336450853 workType "article" @default.