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- W2336472091 abstract "Asthenic symptoms such as weakness accompany illness. This study investigates whether the centrally acting cholinergic agent, vitamin B analogue (sulbutiamine), is effective and acceptable in relieving these symptoms in infectious disease when combined with specific anti-infective treatment.In a prospective uncontrolled, non-randomised, commercial, observational study, 1772 patients with an infectious disease and asthenic symptoms, drawn from the practice of 350 randomly selected physicians throughout India, received vitamin B analogue (sulbutiamine) in addition to specific anti-infective treatment for 15 days. The primary outcome variable was complete resolution of asthenic symptoms with treatment.The number (%, 95% confidence interval) of patients with complete resolution of all asthenic symptoms was 916 (51.7, 49.4-54). In the remaining patients, severe asthenia was reduced but persisted in 11 (0.6, 0-26); and moderate asthenia in 94 (5.3, 0-17.6). The response was greater in patients with acute infection and symptoms more related to cerebral function. Side effects occurred in 10 (0.6%), patients and well being improved significantly.Vitamin B analogue (sulbutiamine) may be a useful adjunct to specific anti-infective treatment." @default.
- W2336472091 created "2016-06-24" @default.
- W2336472091 creator A5059454142 @default.
- W2336472091 date "2003-09-01" @default.
- W2336472091 modified "2023-09-23" @default.
- W2336472091 title "Adjuvant role of vitamin B analogue (sulbutiamine) with anti-infective treatment in infection associated asthenia." @default.
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