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- W2336474906 abstract "Crohn's disease is an immune-mediated disease that results in panenteric chronic inflammation in genetically predisposed individuals exposed to an appropriate environment. The past two decades have witnessed the emergence of an important class of drugs known as anti-tumour necrosis factor (TNF) agents in the treatment of Crohn's disease. Unfortunately, the utility of these agents have been hampered by primary and secondary nonresponse in a significant proportion of patients. Ustekinumab, a monoclonal antibody to the p40 subunit of interleukin (IL) 12 and 23, is a novel pharmacotherapy for this patient cohort that offers an out-of-class option. It is approved for use in psoriasis and psoriatic arthritis, and has now been evaluated in phase II trials for moderate-to-severe Crohn's disease. We here review the published literature and describe a potential clinical role for its use in this disease cohort." @default.
- W2336474906 created "2016-06-24" @default.
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- W2336474906 date "2015-11-26" @default.
- W2336474906 modified "2023-10-12" @default.
- W2336474906 title "Ustekinumab for the treatment of Crohn’s disease: can it find its niche?" @default.
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- W2336474906 doi "https://doi.org/10.1177/1756283x15618130" @default.
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