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- W2336493531 abstract "Abstract The mechanisms by which a cell ends its existence are diverse. It has become clear that each form of cell death has a profound pathogenic relevance in systemic lupus erythematous. Apoptotic cell death provides autoantigens to fuel the aberrant immune response, and its impairment allows autoreactivity to thrive. Autophagy has implications for autoantigen presentation and survival of autoreactive B cells. Finally, necrotic cell death provides the inflammatory milieu to sustain autoimmunity. Our understanding of lupus pathogenesis has dramatically increased and has culminated in the first approval of a specific treatment after a hiatus of more than 50 years. Sophisticated manipulation of the various forms of cell death will lead to a further understanding of lupus and to innovative treatments for this still life-threatening disease." @default.
- W2336493531 created "2016-06-24" @default.
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- W2336493531 date "2016-01-01" @default.
- W2336493531 modified "2023-09-27" @default.
- W2336493531 title "Apoptosis, Autophagy, and Necrosis" @default.
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- W2336493531 doi "https://doi.org/10.1016/b978-0-12-801917-7.00021-8" @default.
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