Matches in SemOpenAlex for { <https://semopenalex.org/work/W2336549548> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2336549548 endingPage "298" @default.
- W2336549548 startingPage "293" @default.
- W2336549548 abstract "Chimeric proteins from chicken and yeast calmodulin were prepared, and roles of three structural domains, N-domain (1-72), central helix (73-87) and C-domain (88-148), were evaluated. Mutants with the chicken-type C-domain activated the cyclic nucleotide phosphodiesterase with small values of Kact (the concentration of calmodulin giving a half maximal activation), a property of chicken calmodulin. On the other hand mutants with the yeast-type C-domain activated the phosphodiesterase with μM range of Kact, a property of yeast calmodulin. In activation of myosin light chain kinase, introduction of the yeast-type C-domain into chicken calmodulin increased the Kact value by more than 1000-fold with a dramatic decrease in the maximum activity (Vmax). On the other hand introduction of the chicken-type C-domain led to a profile with lower Kact and higher Vmax. Minor effects on Vmax and Kact were observed by substitution of the central helix. Although various small contributions of the N-domain were observed, a common role of the chicken-type C-domain was suggested to catch and maintain the high-affinity interaction with target enzymes." @default.
- W2336549548 created "2016-06-24" @default.
- W2336549548 creator A5010975602 @default.
- W2336549548 creator A5019093684 @default.
- W2336549548 creator A5031438140 @default.
- W2336549548 creator A5068941563 @default.
- W2336549548 creator A5088781566 @default.
- W2336549548 date "1995-01-01" @default.
- W2336549548 modified "2023-09-23" @default.
- W2336549548 title "The C-terminal Half-molecular Domain of Calmodulin is Responsible for High-affinity Interaction with Target Enzymes." @default.
- W2336549548 hasPublicationYear "1995" @default.
- W2336549548 type Work @default.
- W2336549548 sameAs 2336549548 @default.
- W2336549548 citedByCount "0" @default.
- W2336549548 crossrefType "journal-article" @default.
- W2336549548 hasAuthorship W2336549548A5010975602 @default.
- W2336549548 hasAuthorship W2336549548A5019093684 @default.
- W2336549548 hasAuthorship W2336549548A5031438140 @default.
- W2336549548 hasAuthorship W2336549548A5068941563 @default.
- W2336549548 hasAuthorship W2336549548A5088781566 @default.
- W2336549548 hasConcept C104317684 @default.
- W2336549548 hasConcept C134306372 @default.
- W2336549548 hasConcept C143065580 @default.
- W2336549548 hasConcept C181199279 @default.
- W2336549548 hasConcept C185592680 @default.
- W2336549548 hasConcept C18903297 @default.
- W2336549548 hasConcept C207583985 @default.
- W2336549548 hasConcept C2778530040 @default.
- W2336549548 hasConcept C2779222958 @default.
- W2336549548 hasConcept C2779965526 @default.
- W2336549548 hasConcept C2780215583 @default.
- W2336549548 hasConcept C29688787 @default.
- W2336549548 hasConcept C33923547 @default.
- W2336549548 hasConcept C36503486 @default.
- W2336549548 hasConcept C55493867 @default.
- W2336549548 hasConcept C62826618 @default.
- W2336549548 hasConcept C6997183 @default.
- W2336549548 hasConcept C8035138 @default.
- W2336549548 hasConcept C86803240 @default.
- W2336549548 hasConceptScore W2336549548C104317684 @default.
- W2336549548 hasConceptScore W2336549548C134306372 @default.
- W2336549548 hasConceptScore W2336549548C143065580 @default.
- W2336549548 hasConceptScore W2336549548C181199279 @default.
- W2336549548 hasConceptScore W2336549548C185592680 @default.
- W2336549548 hasConceptScore W2336549548C18903297 @default.
- W2336549548 hasConceptScore W2336549548C207583985 @default.
- W2336549548 hasConceptScore W2336549548C2778530040 @default.
- W2336549548 hasConceptScore W2336549548C2779222958 @default.
- W2336549548 hasConceptScore W2336549548C2779965526 @default.
- W2336549548 hasConceptScore W2336549548C2780215583 @default.
- W2336549548 hasConceptScore W2336549548C29688787 @default.
- W2336549548 hasConceptScore W2336549548C33923547 @default.
- W2336549548 hasConceptScore W2336549548C36503486 @default.
- W2336549548 hasConceptScore W2336549548C55493867 @default.
- W2336549548 hasConceptScore W2336549548C62826618 @default.
- W2336549548 hasConceptScore W2336549548C6997183 @default.
- W2336549548 hasConceptScore W2336549548C8035138 @default.
- W2336549548 hasConceptScore W2336549548C86803240 @default.
- W2336549548 hasIssue "9" @default.
- W2336549548 hasLocation W23365495481 @default.
- W2336549548 hasOpenAccess W2336549548 @default.
- W2336549548 hasPrimaryLocation W23365495481 @default.
- W2336549548 hasRelatedWork W1526906553 @default.
- W2336549548 hasRelatedWork W1535121904 @default.
- W2336549548 hasRelatedWork W1598429267 @default.
- W2336549548 hasRelatedWork W1670623565 @default.
- W2336549548 hasRelatedWork W1798609471 @default.
- W2336549548 hasRelatedWork W1881288703 @default.
- W2336549548 hasRelatedWork W1988251156 @default.
- W2336549548 hasRelatedWork W1989361508 @default.
- W2336549548 hasRelatedWork W2001667880 @default.
- W2336549548 hasRelatedWork W2037668423 @default.
- W2336549548 hasRelatedWork W2041927385 @default.
- W2336549548 hasRelatedWork W2042675658 @default.
- W2336549548 hasRelatedWork W2068333789 @default.
- W2336549548 hasRelatedWork W2074782503 @default.
- W2336549548 hasRelatedWork W2075691686 @default.
- W2336549548 hasRelatedWork W2091110596 @default.
- W2336549548 hasRelatedWork W2104472885 @default.
- W2336549548 hasRelatedWork W2132859854 @default.
- W2336549548 hasRelatedWork W2314621022 @default.
- W2336549548 hasRelatedWork W2341106386 @default.
- W2336549548 hasVolume "71" @default.
- W2336549548 isParatext "false" @default.
- W2336549548 isRetracted "false" @default.
- W2336549548 magId "2336549548" @default.
- W2336549548 workType "article" @default.