Matches in SemOpenAlex for { <https://semopenalex.org/work/W2336552162> ?p ?o ?g. }
- W2336552162 abstract "Regulatory T cells (Tregs) expand in peripheral lymphoid organs and can produce immunosuppressive cytokines to support tumor growth. IL-10 abrogation efficiently induces Treg formation but dampens tumoral neuropilin-1 (Nrp-1) Treg signaling, which simultaneously augments Th1 and Th17 immunity. These effects are associated with the plasticity and stability of Tregs and effector T cell functions that can limit tumorigenesis. Within the tumor microenvironment, there appears to be a mutual antagonism between immunoenhancement and immunosuppression mechanisms, eventually leading to decreased metastasis. In contrast, tumor progression is paralleled by a reduction in Nrp-1-producing Tregs controlled by the IL-10 and TGF-β1 levels. However, Th1, Th17 and Treg immunity is primarily regulated by IL-10 or Nrp-1 and not TGF-β1 except when combined with IL-10. These results emphasize the important implications for the therapeutic use of Tregs. The number of Treg cells must be maintained in a healthy and dynamic homeostatic range to prevent malignant diseases. Moreover, Treg-mediated immunosuppression can be limited by reducing tumor-derived Treg Nrp-1 levels." @default.
- W2336552162 created "2016-06-24" @default.
- W2336552162 creator A5001994672 @default.
- W2336552162 creator A5032702389 @default.
- W2336552162 creator A5038385200 @default.
- W2336552162 creator A5046597133 @default.
- W2336552162 creator A5053217157 @default.
- W2336552162 creator A5061547469 @default.
- W2336552162 creator A5083314011 @default.
- W2336552162 creator A5090403310 @default.
- W2336552162 date "2016-04-14" @default.
- W2336552162 modified "2023-10-14" @default.
- W2336552162 title "Interleukin-10 deficiency impairs regulatory T cell-derived neuropilin-1 functions and promotes Th1 and Th17 immunity" @default.
- W2336552162 cites W1566992315 @default.
- W2336552162 cites W1612533388 @default.
- W2336552162 cites W1637461528 @default.
- W2336552162 cites W1713837849 @default.
- W2336552162 cites W1954030774 @default.
- W2336552162 cites W1971595657 @default.
- W2336552162 cites W1982006380 @default.
- W2336552162 cites W1982180094 @default.
- W2336552162 cites W1982448824 @default.
- W2336552162 cites W1990295999 @default.
- W2336552162 cites W1992662011 @default.
- W2336552162 cites W1994880314 @default.
- W2336552162 cites W1998387067 @default.
- W2336552162 cites W1998766575 @default.
- W2336552162 cites W2005454098 @default.
- W2336552162 cites W2012680181 @default.
- W2336552162 cites W2014895337 @default.
- W2336552162 cites W2022996006 @default.
- W2336552162 cites W2031222013 @default.
- W2336552162 cites W2032368145 @default.
- W2336552162 cites W2034662723 @default.
- W2336552162 cites W2034875062 @default.
- W2336552162 cites W2038689503 @default.
- W2336552162 cites W2039855270 @default.
- W2336552162 cites W2042349690 @default.
- W2336552162 cites W2053418050 @default.
- W2336552162 cites W2059377172 @default.
- W2336552162 cites W2060185417 @default.
- W2336552162 cites W2060905466 @default.
- W2336552162 cites W2065540590 @default.
- W2336552162 cites W2067885308 @default.
- W2336552162 cites W2072853625 @default.
- W2336552162 cites W2074006404 @default.
- W2336552162 cites W2088251314 @default.
- W2336552162 cites W2088570448 @default.
- W2336552162 cites W2092975931 @default.
- W2336552162 cites W2098124513 @default.
- W2336552162 cites W2100314344 @default.
- W2336552162 cites W2101017584 @default.
- W2336552162 cites W2105983154 @default.
- W2336552162 cites W2112078298 @default.
- W2336552162 cites W2112498628 @default.
- W2336552162 cites W2119444855 @default.
- W2336552162 cites W2121870777 @default.
- W2336552162 cites W2127533496 @default.
- W2336552162 cites W2129932872 @default.
- W2336552162 cites W2134648443 @default.
- W2336552162 cites W2137745956 @default.
- W2336552162 cites W2141783094 @default.
- W2336552162 cites W2143986607 @default.
- W2336552162 cites W2157669002 @default.
- W2336552162 cites W2159987448 @default.
- W2336552162 cites W2166438464 @default.
- W2336552162 cites W2166798619 @default.
- W2336552162 cites W2168637154 @default.
- W2336552162 cites W2171544300 @default.
- W2336552162 cites W2328310341 @default.
- W2336552162 cites W2737785069 @default.
- W2336552162 cites W2784110492 @default.
- W2336552162 doi "https://doi.org/10.1038/srep24249" @default.
- W2336552162 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4831052" @default.
- W2336552162 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27075020" @default.
- W2336552162 hasPublicationYear "2016" @default.
- W2336552162 type Work @default.
- W2336552162 sameAs 2336552162 @default.
- W2336552162 citedByCount "59" @default.
- W2336552162 countsByYear W23365521622016 @default.
- W2336552162 countsByYear W23365521622017 @default.
- W2336552162 countsByYear W23365521622018 @default.
- W2336552162 countsByYear W23365521622019 @default.
- W2336552162 countsByYear W23365521622020 @default.
- W2336552162 countsByYear W23365521622021 @default.
- W2336552162 countsByYear W23365521622022 @default.
- W2336552162 countsByYear W23365521622023 @default.
- W2336552162 crossrefType "journal-article" @default.
- W2336552162 hasAuthorship W2336552162A5001994672 @default.
- W2336552162 hasAuthorship W2336552162A5032702389 @default.
- W2336552162 hasAuthorship W2336552162A5038385200 @default.
- W2336552162 hasAuthorship W2336552162A5046597133 @default.
- W2336552162 hasAuthorship W2336552162A5053217157 @default.
- W2336552162 hasAuthorship W2336552162A5061547469 @default.
- W2336552162 hasAuthorship W2336552162A5083314011 @default.
- W2336552162 hasAuthorship W2336552162A5090403310 @default.
- W2336552162 hasBestOaLocation W23365521621 @default.
- W2336552162 hasConcept C118131993 @default.
- W2336552162 hasConcept C167734588 @default.
- W2336552162 hasConcept C203014093 @default.