FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2336645566> ?p ?o ?g. }

• W2336645566 endingPage "436" @default.
• W2336645566 startingPage "430" @default.
• W2336645566 abstract "Colorectal cancer (CRC) is the third most commonly diagnosed cancer worldwide, with the mortality increasing steadily over the last decade. Myosin VI (MYO6) expression is found to be elevated in some types of human carcinoma cell types, suggesting that it may be a sensitive biomarker for the diagnosis and follow-up. In this study, we first used the Oncomine database to explore the expression of MYO6 in CRC tissues, and then constructed a plasmid of RNA interference targeting MYO6 gene. After transfection of lentivirus targeting MYO6 into SW1116 cells, cell viability and proliferation were measured with 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and colony formation assay. Cell cycle distribution was assayed by flow cytometry and apoptosis was evaluated by Annexin V. MYO6 expression was detected by quantitative real-time polymerase chain reaction and western blot analysis. It was found that MYO6 mRNA was upregulated in CRC tissues using data mining of public Oncomine microarray datasets. Depletion of MYO6 significantly inhibited cell proliferation and colony formation. In addition, knockdown of MYO6 slightly arrested cell cycle in G0/G1 phase, but remarkably increased the proportion of the sub-G1 phase of cell with the increase of apoptotic cells. These results suggest that MYO6 may promote cell growth and may be used as a potential target for anticancer therapy of CRC." @default.
• W2336645566 created "2016-06-24" @default.
• W2336645566 creator A5020004419 @default.
• W2336645566 creator A5031458979 @default.
• W2336645566 creator A5031574868 @default.
• W2336645566 creator A5040135272 @default.
• W2336645566 creator A5060185042 @default.
• W2336645566 creator A5071494012 @default.
• W2336645566 creator A5082805130 @default.
• W2336645566 creator A5087891437 @default.
• W2336645566 date "2016-05-01" @default.
• W2336645566 modified "2023-10-14" @default.
• W2336645566 title "Downregulation of myosin VI reduced cell growth and increased apoptosis in human colorectal cancer" @default.
• W2336645566 cites W1070501797 @default.
• W2336645566 cites W1963592300 @default.
• W2336645566 cites W1972405217 @default.
• W2336645566 cites W1977918192 @default.
• W2336645566 cites W1982861164 @default.
• W2336645566 cites W1984214960 @default.
• W2336645566 cites W1992590802 @default.
• W2336645566 cites W2006029639 @default.
• W2336645566 cites W2009123057 @default.
• W2336645566 cites W2013425501 @default.
• W2336645566 cites W2025326932 @default.
• W2336645566 cites W2033768652 @default.
• W2336645566 cites W2045137400 @default.
• W2336645566 cites W2047769211 @default.
• W2336645566 cites W2050245934 @default.
• W2336645566 cites W2082333417 @default.
• W2336645566 cites W2087266324 @default.
• W2336645566 cites W2091044390 @default.
• W2336645566 cites W2103586281 @default.
• W2336645566 cites W2106787323 @default.
• W2336645566 cites W2108900994 @default.
• W2336645566 cites W2109303707 @default.
• W2336645566 cites W2113962581 @default.
• W2336645566 cites W2125764173 @default.
• W2336645566 cites W2127016760 @default.
• W2336645566 cites W2127594372 @default.
• W2336645566 cites W2130758161 @default.
• W2336645566 cites W2135056923 @default.
• W2336645566 cites W2147297736 @default.
• W2336645566 cites W2147952777 @default.
• W2336645566 cites W2155354546 @default.
• W2336645566 cites W2158898536 @default.
• W2336645566 cites W2159365006 @default.
• W2336645566 cites W2159400887 @default.
• W2336645566 cites W2161409973 @default.
• W2336645566 doi "https://doi.org/10.1093/abbs/gmw020" @default.
• W2336645566 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7190026" @default.
• W2336645566 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29608642" @default.
• W2336645566 hasPublicationYear "2016" @default.
• W2336645566 type Work @default.
• W2336645566 sameAs 2336645566 @default.
• W2336645566 citedByCount "21" @default.
• W2336645566 countsByYear W23366455662016 @default.
• W2336645566 countsByYear W23366455662017 @default.
• W2336645566 countsByYear W23366455662018 @default.
• W2336645566 countsByYear W23366455662019 @default.
• W2336645566 countsByYear W23366455662020 @default.
• W2336645566 countsByYear W23366455662021 @default.
• W2336645566 countsByYear W23366455662022 @default.
• W2336645566 countsByYear W23366455662023 @default.
• W2336645566 crossrefType "journal-article" @default.
• W2336645566 hasAuthorship W2336645566A5020004419 @default.
• W2336645566 hasAuthorship W2336645566A5031458979 @default.
• W2336645566 hasAuthorship W2336645566A5031574868 @default.
• W2336645566 hasAuthorship W2336645566A5040135272 @default.
• W2336645566 hasAuthorship W2336645566A5060185042 @default.
• W2336645566 hasAuthorship W2336645566A5071494012 @default.
• W2336645566 hasAuthorship W2336645566A5082805130 @default.
• W2336645566 hasAuthorship W2336645566A5087891437 @default.
• W2336645566 hasBestOaLocation W23366455661 @default.
• W2336645566 hasConcept C104317684 @default.
• W2336645566 hasConcept C121608353 @default.
• W2336645566 hasConcept C127561419 @default.
• W2336645566 hasConcept C1491633281 @default.
• W2336645566 hasConcept C153911025 @default.
• W2336645566 hasConcept C173396325 @default.
• W2336645566 hasConcept C190283241 @default.
• W2336645566 hasConcept C29537977 @default.
• W2336645566 hasConcept C502942594 @default.
• W2336645566 hasConcept C526805850 @default.
• W2336645566 hasConcept C53227056 @default.
• W2336645566 hasConcept C54009773 @default.
• W2336645566 hasConcept C54355233 @default.
• W2336645566 hasConcept C553184892 @default.
• W2336645566 hasConcept C55493867 @default.
• W2336645566 hasConcept C62112901 @default.
• W2336645566 hasConcept C6997183 @default.
• W2336645566 hasConcept C81885089 @default.
• W2336645566 hasConcept C86803240 @default.
• W2336645566 hasConcept C95444343 @default.
• W2336645566 hasConceptScore W2336645566C104317684 @default.
• W2336645566 hasConceptScore W2336645566C121608353 @default.
• W2336645566 hasConceptScore W2336645566C127561419 @default.
• W2336645566 hasConceptScore W2336645566C1491633281 @default.
• W2336645566 hasConceptScore W2336645566C153911025 @default.

• next