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• W2336657079 abstract "Objective: To characterize atypical hemorrhages using clinical and neuroimaging profiles.Background: Moyamoya disease is an uncommon cerebral vasculopathy characterized by progressive steno-occlusive changes of the large, mainly anterior circulation, intracranial vessels. Chronic ischemia is thought to lead to development of moyamoya, leptomeningeal and dural-pial collateral vessels. Intracranial hemorrhage (ICH) occurring in deep brain structures is a common presentation in adults. Our goal is to characterize atypical hemorrhages.Methods:We analyzed clinical and radiological data of 13 patients with moyamoya disease presenting with ICH. Hemorrhages were divided into typical (basal ganglia, thalamus) and atypical (lobar, subarachnoid hemorrhage (SAH)) locations. Data collected include age, gender, atherosclerotic risk factors, concomitant antithrombotic use, and previous history of ICH. Laboratory results, brain MRI, MRA NOVA, and cerebral angiograms were analyzed.Results: Atypical hemorrhages were found in 6/13 (46[percnt]) patients (3 SAH, 2 lobar parenchymal hematoma, 1 splenial hemorrhage). Most atypical hemorrhages (5/6, 83[percnt]) involved the anterior circulation. Past ICH was only observed in the atypical group (4/6 (67[percnt]) vs. 0/7). Comparing atypical to typical ICH, female gender (3/6 (50[percnt]) vs. 6/7 (86[percnt])), vascular risk factors (3/6 (50[percnt]) vs. 5/7 (71[percnt])) and concurrent antithrombotic use (2/6 (33[percnt]) vs. 5/7 (71[percnt])) were less common in the atypical group. No differences were observed in age, race, and admission BP and laboratory values. Arterial blood flow, measured by MRA NOVA and confirmed by conventional angiogram, was decreased or absent ipsilateral to the ICH in both groups signifying hemodynamic compromise in the corresponding vascular territories, without observable difference between groups.Conclusions:Atypical hemorrhages were found in 46[percnt] of patients with hemorrhagic moyamoya disease in our series. Previous history of ICH may be associated while vascular risk factors, female gender and concomitant antithrombotic use may portend typical hemorrhage locations. Larger series may be required to differentiate imaging characteristics between these ICH subgroups. Disclosure: Dr. Mishra has nothing to disclose. Dr. Patel has nothing to disclose. Dr. Pishanidar has nothing to disclose. Dr. Rube has nothing to disclose. Dr. Burshtein has nothing to disclose. Dr. Tversky has nothing to disclose. Dr. Kodankandath has nothing to disclose. Dr. Seyoum has nothing to disclose. Dr. Dehdashti has nothing to disclose. Dr. Langer has nothing to disclose. Dr. Wright has nothing to disclose. Dr. Libman has nothing to disclose. Dr. Katz has nothing to disclose." @default.
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• W2336657079 date "2016-04-05" @default.
• W2336657079 modified "2023-09-27" @default.
• W2336657079 title "Characteristics of Atypical Intracranial Hemorrhage in Moyamoya Disease: A Case Series (P4.384)" @default.
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