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• W2336659126 abstract "Objective The aim of this study was to induce a rat model of oral submucous fibrosis (OSF) using bleomycin. Study Design A randomized trial was performed. Bleomycin dilution or phosphate-buffered saline was injected daily into the buccal mucosa of the test and control rats, respectively, for 2, 4, 6, or 8 weeks. Changes in histopathologic features, myofibroblasts, ultrastructure, and the levels of collagen type I and III, transforming growth factor–beta 1, and interferon-γ were measured. Results Compared with controls, the buccal mucosa of the test rats appeared pale and stiff. There was collagen deposition in the laminae propria. Type I and type III collagen increased steadily, transforming growth factor–beta 1 increased and then decreased, and interferon-γ was gradually reduced. The ultrastructure was also similar to that of OSF. Conclusions Using bleomycin, we induced a rat model of OSF that is very similar to human OSF in clinical manifestations, pathology, and ultrastructural changes. The aim of this study was to induce a rat model of oral submucous fibrosis (OSF) using bleomycin. A randomized trial was performed. Bleomycin dilution or phosphate-buffered saline was injected daily into the buccal mucosa of the test and control rats, respectively, for 2, 4, 6, or 8 weeks. Changes in histopathologic features, myofibroblasts, ultrastructure, and the levels of collagen type I and III, transforming growth factor–beta 1, and interferon-γ were measured. Compared with controls, the buccal mucosa of the test rats appeared pale and stiff. There was collagen deposition in the laminae propria. Type I and type III collagen increased steadily, transforming growth factor–beta 1 increased and then decreased, and interferon-γ was gradually reduced. The ultrastructure was also similar to that of OSF. Using bleomycin, we induced a rat model of OSF that is very similar to human OSF in clinical manifestations, pathology, and ultrastructural changes." @default.
• W2336659126 created "2016-06-24" @default.
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• W2336659126 date "2016-08-01" @default.
• W2336659126 modified "2023-10-16" @default.
• W2336659126 title "A rat model of oral submucous fibrosis induced by bleomycin" @default.
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• W2336659126 doi "https://doi.org/10.1016/j.oooo.2015.07.042" @default.
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