FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2336680621> ?p ?o ?g. }

• W2336680621 abstract "Systemic antibiotics vary widely in in vitro activity against Clostridium difficile. Some agents with activity against C. difficile (e.g., piperacillin/tazobactam) inhibit establishment of colonization in mice. We tested the hypothesis that piperacillin/tazobactam and other agents with activity against C. difficile achieve sufficient concentrations in the intestinal tract to inhibit colonization in patients.Point-prevalence culture surveys were conducted to compare the frequency of asymptomatic rectal carriage of toxigenic C. difficile among patients receiving piperacillin/tazobactam or other inhibitory antibiotics (e.g. ampicillin, linezolid, carbapenems) versus antibiotics lacking activity against C. difficile (e.g., cephalosporins, ciprofloxacin). For a subset of patients, in vitro inhibition of C. difficile (defined as a reduction in concentration after inoculation of vegetative C. difficile into fresh stool suspensions) was compared among antibiotic treatment groups.Of 250 patients, 32 (13 %) were asymptomatic carriers of C. difficile. In comparison to patients receiving non-inhibitory antibiotics or prior antibiotics within 90 days, patients currently receiving piperacillin/tazobactam were less likely to be asymptomatic carriers (1/36, 3 versus 7/36, 19 and 15/69, 22 %, respectively; P = 0.024) and more likely to have fecal suspensions with in vitro inhibitory activity against C. difficile (20/28, 71 versus 3/11, 27 and 4/26, 15 %; P = 0.03). Patients receiving other inhibitory antibiotics were not less likely to be asymptomatic carriers than those receiving non-inhibitory antibiotics.Our findings suggest that piperacillin/tazobactam achieves sufficient concentrations in the intestinal tract to inhibit C. difficile colonization during therapy." @default.
• W2336680621 created "2016-06-24" @default.
• W2336680621 creator A5014770089 @default.
• W2336680621 creator A5014948117 @default.
• W2336680621 creator A5036038988 @default.
• W2336680621 creator A5047255072 @default.
• W2336680621 creator A5048908269 @default.
• W2336680621 creator A5051657172 @default.
• W2336680621 creator A5058899660 @default.
• W2336680621 creator A5066012627 @default.
• W2336680621 date "2016-04-18" @default.
• W2336680621 modified "2023-10-16" @default.
• W2336680621 title "Do piperacillin/tazobactam and other antibiotics with inhibitory activity against Clostridium difficile reduce the risk for acquisition of C. difficile colonization?" @default.
• W2336680621 cites W1974640328 @default.
• W2336680621 cites W2011102897 @default.
• W2336680621 cites W2042879025 @default.
• W2336680621 cites W2049176766 @default.
• W2336680621 cites W2055385942 @default.
• W2336680621 cites W2056233510 @default.
• W2336680621 cites W2080549997 @default.
• W2336680621 cites W2094975634 @default.
• W2336680621 cites W2095681266 @default.
• W2336680621 cites W2097341466 @default.
• W2336680621 cites W2101190161 @default.
• W2336680621 cites W2111990189 @default.
• W2336680621 cites W2112669742 @default.
• W2336680621 cites W2113585244 @default.
• W2336680621 cites W2133178033 @default.
• W2336680621 cites W2143005471 @default.
• W2336680621 cites W2146624345 @default.
• W2336680621 cites W2147108635 @default.
• W2336680621 cites W2148982748 @default.
• W2336680621 cites W2157261845 @default.
• W2336680621 cites W2157461928 @default.
• W2336680621 cites W2158188386 @default.
• W2336680621 cites W2165003341 @default.
• W2336680621 cites W2165811639 @default.
• W2336680621 doi "https://doi.org/10.1186/s12879-016-1514-2" @default.
• W2336680621 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4835867" @default.
• W2336680621 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27091232" @default.
• W2336680621 hasPublicationYear "2016" @default.
• W2336680621 type Work @default.
• W2336680621 sameAs 2336680621 @default.
• W2336680621 citedByCount "34" @default.
• W2336680621 countsByYear W23366806212017 @default.
• W2336680621 countsByYear W23366806212018 @default.
• W2336680621 countsByYear W23366806212019 @default.
• W2336680621 countsByYear W23366806212020 @default.
• W2336680621 countsByYear W23366806212021 @default.
• W2336680621 countsByYear W23366806212022 @default.
• W2336680621 countsByYear W23366806212023 @default.
• W2336680621 crossrefType "journal-article" @default.
• W2336680621 hasAuthorship W2336680621A5014770089 @default.
• W2336680621 hasAuthorship W2336680621A5014948117 @default.
• W2336680621 hasAuthorship W2336680621A5036038988 @default.
• W2336680621 hasAuthorship W2336680621A5047255072 @default.
• W2336680621 hasAuthorship W2336680621A5048908269 @default.
• W2336680621 hasAuthorship W2336680621A5051657172 @default.
• W2336680621 hasAuthorship W2336680621A5058899660 @default.
• W2336680621 hasAuthorship W2336680621A5066012627 @default.
• W2336680621 hasBestOaLocation W23366806211 @default.
• W2336680621 hasConcept C126322002 @default.
• W2336680621 hasConcept C2777637488 @default.
• W2336680621 hasConcept C2777858937 @default.
• W2336680621 hasConcept C2778193466 @default.
• W2336680621 hasConcept C2778266534 @default.
• W2336680621 hasConcept C2779631663 @default.
• W2336680621 hasConcept C2994496256 @default.
• W2336680621 hasConcept C501593827 @default.
• W2336680621 hasConcept C523546767 @default.
• W2336680621 hasConcept C54355233 @default.
• W2336680621 hasConcept C71924100 @default.
• W2336680621 hasConcept C86803240 @default.
• W2336680621 hasConcept C89423630 @default.
• W2336680621 hasConcept C94665300 @default.
• W2336680621 hasConceptScore W2336680621C126322002 @default.
• W2336680621 hasConceptScore W2336680621C2777637488 @default.
• W2336680621 hasConceptScore W2336680621C2777858937 @default.
• W2336680621 hasConceptScore W2336680621C2778193466 @default.
• W2336680621 hasConceptScore W2336680621C2778266534 @default.
• W2336680621 hasConceptScore W2336680621C2779631663 @default.
• W2336680621 hasConceptScore W2336680621C2994496256 @default.
• W2336680621 hasConceptScore W2336680621C501593827 @default.
• W2336680621 hasConceptScore W2336680621C523546767 @default.
• W2336680621 hasConceptScore W2336680621C54355233 @default.
• W2336680621 hasConceptScore W2336680621C71924100 @default.
• W2336680621 hasConceptScore W2336680621C86803240 @default.
• W2336680621 hasConceptScore W2336680621C89423630 @default.
• W2336680621 hasConceptScore W2336680621C94665300 @default.
• W2336680621 hasFunder F4320306127 @default.
• W2336680621 hasIssue "1" @default.
• W2336680621 hasLocation W23366806211 @default.
• W2336680621 hasLocation W23366806212 @default.
• W2336680621 hasLocation W23366806213 @default.
• W2336680621 hasLocation W23366806214 @default.
• W2336680621 hasOpenAccess W2336680621 @default.
• W2336680621 hasPrimaryLocation W23366806211 @default.
• W2336680621 hasRelatedWork W1837797665 @default.
• W2336680621 hasRelatedWork W2026293122 @default.
• W2336680621 hasRelatedWork W2036967640 @default.

• next