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- W2336691821 abstract "In utero maternal immune activation (MIA) and cannabinoid exposure during adolescence constitute environmental risk factors for schizophrenia. We investigated these risk factors alone and in combination (two-hit) on epidermal growth factor receptor (EGFR) and neuregulin-1 receptor (ErbB4) levels in the rat brain. EGFR but not ErbB4 receptor protein levels were significantly increased in the nucleus accumbens and striatum of two-hit rats only, with no changes seen at the mRNA level. These findings support region specific EGF-system dysregulation as a plausible mechanism in this animal model of schizophrenia pathogenesis." @default.
- W2336691821 created "2016-06-24" @default.
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- W2336691821 date "2016-06-01" @default.
- W2336691821 modified "2023-09-29" @default.
- W2336691821 title "Striatal but not frontal cortical up-regulation of the epidermal growth factor receptor in rats exposed to immune activation in utero and cannabinoid treatment in adolescence" @default.
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- W2336691821 doi "https://doi.org/10.1016/j.psychres.2016.04.026" @default.
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