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• W2336694728 abstract "Event Abstract Back to Event 3D printed microfluidics for blood filtration Stanley Bilatto1, 2, 3, Alexey Yakushenko3, Daniel S. Corrêa1, 2, Bernhard Wolfrum3, 4 and Andreas Offenhäusser3 1 Federal University of São Carlos (UFSCar), Chemistry Department, Brazil 2 Embrapa Instrumentation, National Laboratory for Nanotechnology in Agribusiness (LNNA), Brazil 3 Forschungszentrum Jülich, Institute of Bioelectronics (PGI-8/ICS-8) and JARA-Fundamentals of Future Information Technology, Germany 4 Technische Universität München, Neuroelectronics, Department of Electrical and Computer Engineering, Germany The capability to analyze blood plasma proteome is very useful to disease diagnosis and therapeutic monitoring [1], but the time between plasma separation from blood and its analysis is critical for consistent results [2]. The latest advances in nanotechnology, biochemistry and material science combined with the development of affordable miniaturized diagnostic devices enable to develop simple and fast methods to detect and tackle infectious diseases. Recent advances in desktop stereolithographic (SLA) 3D printers enable low-cost rapid prototyping of microfluidic structures reducing the complexity of the design and decreasing the amount of external support equipment required [3]. Previously, plasma separation inside microfluidic devices has been demonstrated using a two-phase plug [4],[5], highly confined microchannels [6], and a stand-alone self-powered integrated microfluidic system [3]. Building on these recent technologies we have developed a microfluidic system to split the plasma from the whole blood instantly. In this work, we have optimized a 3D-printed structure for the separation of plasma from blood based on blood capillary flow into micro channels. Structures were designed to be printed using a standard stereolithographic 3D printer (Miicraft 3D, Hsinchu, Taiwan, 450 ppi). Samples were printed with a layer thickness of 50 µm using UV curable acrylate (Clear Resin BV-003, Young Optics Inc., Hsinchu, Taiwan). After printing, the samples were washed with ethanol to remove uncured resin, dried with nitrogen and post-cured using an integrated UV-Lamp (18W UVA Lamp). Contact angle measurements (68.3 ±2.1o for water) revealed no difference in the surface energy using different post-curing process times ranging from 0 – 1200 s. We investigated the influence of surface treatment with oxygen plasma on the blood flow velocity. The design of the microfluidic geometry was optimized for on-chip plasma separation. After plasma separation, the sample can be directed on-chip for analysis with integrated electrochemical or optical sensors. In summary, we have developed a standalone 3D-printed microfluidic system for passive, i.e. without pumps or vacuum, extraction of plasma from small amounts of whole blood. Capes-PDSE (Process 10585-14-1); Embrapa; UFSCar; Forschungszentrum JülichReferences:[1] The Human Plasma Proteome, Molecular & Cellular Proteomics 1.11, 2002 by The American Society for Biochemistry and Molecular Biology, Inc.[2] Sen-Yung Hsieh, Ren-Kung Chen, Yi-Hsin Pan and Hai-Lun Lee; Proteomics, 2006, 6, 3189–3198.[3] Ivan K. Dimov, Lourdes Basabe-Desmonts, Jose L. Garcia-Cordero, Benjamin M. Ross, Antonio J. Ricco and Luke P. Lee; Lab Chip, 2011, 11, 845–850.[4] Sung Yang, Akif Undar and Jeffrey D. Zahn; Lab Chip, 2006, 6, 871–880.[5] Meng Sun, Zeina S. Khan and Siva A. Vanapalli; Lab Chip, 2012, 12, 5225–5230.[6] Guillermo R. L´azaro, Aurora Hernandez-Machadoa and Ignacio Pagonabarraga; Soft Matter, 2014, 10, 7195. Keywords: biosensing, Lab on a chip, device, biomedical application Conference: 10th World Biomaterials Congress, Montréal, Canada, 17 May - 22 May, 2016. Presentation Type: Poster Topic: Biosensors Citation: Bilatto S, Yakushenko A, Corrêa DS, Wolfrum B and Offenhäusser A (2016). 3D printed microfluidics for blood filtration. Front. Bioeng. Biotechnol. Conference Abstract: 10th World Biomaterials Congress. doi: 10.3389/conf.FBIOE.2016.01.00959 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 27 Mar 2016; Published Online: 30 Mar 2016. Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Stanley Bilatto Alexey Yakushenko Daniel S Corrêa Bernhard Wolfrum Andreas Offenhäusser Google Stanley Bilatto Alexey Yakushenko Daniel S Corrêa Bernhard Wolfrum Andreas Offenhäusser Google Scholar Stanley Bilatto Alexey Yakushenko Daniel S Corrêa Bernhard Wolfrum Andreas Offenhäusser PubMed Stanley Bilatto Alexey Yakushenko Daniel S Corrêa Bernhard Wolfrum Andreas Offenhäusser Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page." @default.
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