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• W2336697091 abstract "Normal-tension glaucoma (NTG) is a multifactorial disease where mechanical stresses and vascular alterations to the optic nerve head probably represent the key pathogenic moments. Although intraocular pressure (IOP) plays a crucial role in the retinal ganglion cell loss, the IOP reduction does not necessarily reduces the disease progression. Therefore, several IOP-independent factors such as glutamate toxicity, oxidative stress, autoimmunity, and vascular dysregulation have been considered in the pathogenesis of NTG. Numerous evidences documented an impairment of the ocular blood flow, involved both in the onset and progression of the disease. The IOP reduction remains the main strategy to reduce the damage progression in NTG. Recently, new treatment strategies have been proposed to improve the control of the disease. Neuroprotection is a rapidly expanding area of research, which represents a promising tool. In the present review, we summarize the recent scientific advancements in the pathogenesis and treatment of NTG." @default.
• W2336697091 created "2016-06-24" @default.
• W2336697091 creator A5000769365 @default.
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• W2336697091 creator A5091398735 @default.
• W2336697091 date "2015-01-01" @default.
• W2336697091 modified "2023-09-25" @default.
• W2336697091 title "Advance in the pathogenesis and treatment of normal-tension glaucoma" @default.
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