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- W2336700951 abstract "Previous studies1-4 have’ suggested that the occurrence of experimentally produced lesions of pulmonary vasculitis in the rabbit actually may be a function of the specificity of this tissue participating in immunologic reactions as a “shock organ.” In these studies, utilization of the technique of passive sensitization and subsequent challenge in rabbits has demonstrated the uniform occurrence of panarteritis and perivascular lesions involving the arterioles and venules resulting from the in vivo antigen-antibody reaction. However, the reason for the localization of these lesions being limited to the pulmonary vasculature is not clearly understood. IIawn5 has observed identical lesions in rabbits subjected to single large injections of bovine serum albumin and bovine serum gamma globulin.G The prerequisites for and the circumstances surrounding the production of these lesions, discussed elsewhere,le3 suggest that these lesions represent tissue manifestations of subacute anaphylaxis without any distinctive characteristics of the tissue response related to the particular antigen-antibody system involved. Thus, localization in a shock organ could explain the site of occurrence of a lesion resulting from an anaphylactic response of any degree of severity or duration of action. However, the question of the importance of the role of the particular route of administration of the antibody and antigen in passive sensitization and challenge experiments must be justifiably considered. The manner of injection could influence the site and character of the resultant tissue alterations so that the intravenous route employed in these studies may predispose" @default.
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- W2336700951 date "1956-01-01" @default.
- W2336700951 modified "2023-09-23" @default.
- W2336700951 title "STUDIES ON THE SPECIFICITY OF SHOCK TISSUE" @default.
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