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- W2336727488 abstract "Abstract Objective : Remifentanil has a unique metabolic pathway that holds potential benefits for long-term sedation. We compared remifentanil-midazolam to sufentanil-midazolam in 41 critically ill adults requiring mechanical ventilation. Study design : Randomized double-blind trial. Patients and methods. – Infusion rates were titrated every 4 hours to achieve the desired Ramsay score. Five fold increases in doserequirement was considered as the development of tolerance. Drugs requirement, development of tolerance and weaning time of ventilationwere compared. Results. – The study was stopped after an interim analysis. The remifentanil and sufentanil groups were comparable regarding IGS II:56 ± 22 vs 64 ± 26, mean ± SD, ICU length of stay: 26 (8-45) vs 19 (11-34) days, and sedation duration: 6 (4-19) vs 6 (3-16)days, median[interquartile range, IQR]). There was a shorter weaning time in the remifentanil group as compared to sufentanil group: 22 h (12-53) vs 96(47-142) h, median [IQR], p" @default.
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- W2336727488 date "2005-01-01" @default.
- W2336727488 modified "2023-09-22" @default.
- W2336727488 title "Rémifentanil-midazolam versus sufentanil-midazolam pour la sédation prolongée en réanimation Remifentanil-midazolam compared to sufentanil-midazolam for ICU long-term sedation" @default.
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