Matches in SemOpenAlex for { <https://semopenalex.org/work/W2336746113> ?p ?o ?g. }
- W2336746113 endingPage "714" @default.
- W2336746113 startingPage "707" @default.
- W2336746113 abstract "Thalidomide is an effective drug for chronic inflammatory diseases, but the mechanism underlying its immunomodulatory action remains uncertain. Thalidomide has been reported to clinically improve chronic inflammatory granulomatous disorders. In such disorders, the granulomas consist of epithelioid cells, scattered lymphocytes and multinucleated giant cells (MNGC; Langhans-type cells). The present experimental approach permitted the reproduction of MNGC formation from peripheral blood monocytes and examination of thalidomide's effect on it. MNGC can be effectively generated from monocytes cultured in the presence of interleukin-4 (IL-4) and macrophage colony-stimulating factor (M-CSF) for 14 days. Thalidomide can inhibit the formation of MNGC in a dose-dependent manner. MNGC formation was partly inhibited by the presence of neutralizing TNF-α antibody in the responses induced by IL-4 and M-CSF. Autocrinal TNF-α production and modulation of cadhelin expression to regulate cell adhesion might be involved in this inhibitory action of thalidomide. Our results support thalidomide's clinical efficacy in the treatment of chronic granulomatous disorders (granulomatosis)." @default.
- W2336746113 created "2016-06-24" @default.
- W2336746113 creator A5022970301 @default.
- W2336746113 creator A5030354630 @default.
- W2336746113 creator A5037688173 @default.
- W2336746113 creator A5046787879 @default.
- W2336746113 creator A5067372257 @default.
- W2336746113 creator A5070031397 @default.
- W2336746113 creator A5077406348 @default.
- W2336746113 creator A5090443987 @default.
- W2336746113 date "2009-07-01" @default.
- W2336746113 modified "2023-09-26" @default.
- W2336746113 title "Thalidomide Prevents Formation of Multinucleated Giant Cells (Langhans-Type Cells) from Cultured Monocytes: Possible Pharmaceutical Applications for Granulomatous Disorders" @default.
- W2336746113 cites W147454428 @default.
- W2336746113 cites W1501709778 @default.
- W2336746113 cites W1969306694 @default.
- W2336746113 cites W1978640748 @default.
- W2336746113 cites W1986659879 @default.
- W2336746113 cites W1987331822 @default.
- W2336746113 cites W1997317029 @default.
- W2336746113 cites W1998199040 @default.
- W2336746113 cites W1999543608 @default.
- W2336746113 cites W2011405088 @default.
- W2336746113 cites W2014520088 @default.
- W2336746113 cites W2035046934 @default.
- W2336746113 cites W2046285825 @default.
- W2336746113 cites W2052261499 @default.
- W2336746113 cites W2067679507 @default.
- W2336746113 cites W2071742211 @default.
- W2336746113 cites W2074878517 @default.
- W2336746113 cites W2075017432 @default.
- W2336746113 cites W2079190230 @default.
- W2336746113 cites W2081704353 @default.
- W2336746113 cites W2117287541 @default.
- W2336746113 cites W2119457381 @default.
- W2336746113 cites W2130189048 @default.
- W2336746113 cites W2133067740 @default.
- W2336746113 cites W2137798077 @default.
- W2336746113 cites W2142118306 @default.
- W2336746113 cites W2144972769 @default.
- W2336746113 cites W2149049320 @default.
- W2336746113 cites W2158486578 @default.
- W2336746113 cites W2161984863 @default.
- W2336746113 cites W2162559503 @default.
- W2336746113 cites W3022361853 @default.
- W2336746113 cites W3205517494 @default.
- W2336746113 cites W4254966848 @default.
- W2336746113 cites W4313376856 @default.
- W2336746113 doi "https://doi.org/10.1177/039463200902200316" @default.
- W2336746113 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19822087" @default.
- W2336746113 hasPublicationYear "2009" @default.
- W2336746113 type Work @default.
- W2336746113 sameAs 2336746113 @default.
- W2336746113 citedByCount "5" @default.
- W2336746113 countsByYear W23367461132012 @default.
- W2336746113 countsByYear W23367461132015 @default.
- W2336746113 countsByYear W23367461132018 @default.
- W2336746113 countsByYear W23367461132023 @default.
- W2336746113 crossrefType "journal-article" @default.
- W2336746113 hasAuthorship W2336746113A5022970301 @default.
- W2336746113 hasAuthorship W2336746113A5030354630 @default.
- W2336746113 hasAuthorship W2336746113A5037688173 @default.
- W2336746113 hasAuthorship W2336746113A5046787879 @default.
- W2336746113 hasAuthorship W2336746113A5067372257 @default.
- W2336746113 hasAuthorship W2336746113A5070031397 @default.
- W2336746113 hasAuthorship W2336746113A5077406348 @default.
- W2336746113 hasAuthorship W2336746113A5090443987 @default.
- W2336746113 hasConcept C142724271 @default.
- W2336746113 hasConcept C17991360 @default.
- W2336746113 hasConcept C202751555 @default.
- W2336746113 hasConcept C203014093 @default.
- W2336746113 hasConcept C2776364478 @default.
- W2336746113 hasConcept C2779244956 @default.
- W2336746113 hasConcept C2779609412 @default.
- W2336746113 hasConcept C2781184567 @default.
- W2336746113 hasConcept C55493867 @default.
- W2336746113 hasConcept C70508372 @default.
- W2336746113 hasConcept C71924100 @default.
- W2336746113 hasConcept C77076574 @default.
- W2336746113 hasConcept C86803240 @default.
- W2336746113 hasConceptScore W2336746113C142724271 @default.
- W2336746113 hasConceptScore W2336746113C17991360 @default.
- W2336746113 hasConceptScore W2336746113C202751555 @default.
- W2336746113 hasConceptScore W2336746113C203014093 @default.
- W2336746113 hasConceptScore W2336746113C2776364478 @default.
- W2336746113 hasConceptScore W2336746113C2779244956 @default.
- W2336746113 hasConceptScore W2336746113C2779609412 @default.
- W2336746113 hasConceptScore W2336746113C2781184567 @default.
- W2336746113 hasConceptScore W2336746113C55493867 @default.
- W2336746113 hasConceptScore W2336746113C70508372 @default.
- W2336746113 hasConceptScore W2336746113C71924100 @default.
- W2336746113 hasConceptScore W2336746113C77076574 @default.
- W2336746113 hasConceptScore W2336746113C86803240 @default.
- W2336746113 hasIssue "3" @default.
- W2336746113 hasLocation W23367461131 @default.
- W2336746113 hasLocation W23367461132 @default.
- W2336746113 hasOpenAccess W2336746113 @default.
- W2336746113 hasPrimaryLocation W23367461131 @default.