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- W2336751012 endingPage "1113" @default.
- W2336751012 startingPage "1107" @default.
- W2336751012 abstract "In Crohn's disease, one of the two major forms of inflammatory bowel diseases in human beings, persistent and chronic inflammation promotes fibrotic processes thereby facilitating formation of strictures, the most common indication for surgical intervention in this disorder. The pathogenesis of Crohn's disease-associated fibrosis is not fully understood, but variants of genes involved in the recognition of microbial components/products [e.g. CARD15 (caspase-activating recruitment domain 15) and ATG16L1 (autophagy-related 16-like 1)] are associated with this phenotype, and experimental evidence suggests that intestinal fibrosis results from an altered balance between deposition of ECM (extracellular matrix) and degradation of ECM by proteases. Studies have also contributed to identify the main phenotypic and functional alterations of cells involved in the fibrogenic process, as well as molecules that stimulate such cells to produce elevated amounts of collagen and other ECM-related proteins. In the present review, we assess the current knowledge about cellular and molecular mediators of intestinal fibrosis and describe results of recent studies aimed at testing the preventive/therapeutic effect of compounds in experimental models of intestinal fibrosis." @default.
- W2336751012 created "2016-06-24" @default.
- W2336751012 creator A5044577178 @default.
- W2336751012 creator A5066481245 @default.
- W2336751012 creator A5086858016 @default.
- W2336751012 date "2015-10-22" @default.
- W2336751012 modified "2023-10-03" @default.
- W2336751012 title "Pathogenic aspects and therapeutic avenues of intestinal fibrosis in Crohn's disease" @default.
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- W2336751012 doi "https://doi.org/10.1042/cs20150472" @default.