Matches in SemOpenAlex for { <https://semopenalex.org/work/W2336764732> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2336764732 endingPage "620" @default.
- W2336764732 startingPage "615" @default.
- W2336764732 abstract "Objectives: No previous studies have examined the effect of sildenafil on fracture healing. This study was designed to investigate the effect of sildenafil on the fracture healing process. Methods: Thirty-six female Sprague-Dawley rats (3-month-old) were used in this study. Animals were randomly divided into 2 groups based on treatment duration (1 week versus 4 weeks) and each group was then divided further into 2 subgroups, control (C) and study (S) groups. Group C (C1, C2) was treated daily with saline solution and group S (S1, S2) was treated daily with 10 mg/kg of sildenafil. Histologic, histomorphometric, radiological, and immunohistochemical analyses were performed at 1 week and 4 weeks after a fracture. Results: The sildenafil group showed a significant increase in fracture healing scores (P = 0.00). The authors observed a transition from fibrous callus to cartilage tissue and immature bone tissue in group S1; and an increased transition of cartilage tissue to completely immature bone tissue in group S2, both of which were administered sildenafil. The strong expression of bone morphogenetic protein 2 and col-1 was observed in the fibrous matrix and osteoblasts within areas of new bone formation, especially in group S1. This group also showed an increase in bone density measurements at 1 week that was statistically significant (P = 0.03). Conclusions: Sildenafil accelerates fracture healing and can be used as a supporting factor in the improvement of fracture healing under various conditions." @default.
- W2336764732 created "2016-06-24" @default.
- W2336764732 creator A5001180722 @default.
- W2336764732 creator A5004590637 @default.
- W2336764732 creator A5008787316 @default.
- W2336764732 creator A5031600253 @default.
- W2336764732 creator A5039465001 @default.
- W2336764732 creator A5047159659 @default.
- W2336764732 date "2016-05-01" @default.
- W2336764732 modified "2023-09-23" @default.
- W2336764732 title "Therapeutic Effects of Sildenafil on Experimental Mandibular Fractures" @default.
- W2336764732 cites W1913960463 @default.
- W2336764732 cites W1977574369 @default.
- W2336764732 cites W1997649977 @default.
- W2336764732 cites W1997768760 @default.
- W2336764732 cites W2006234048 @default.
- W2336764732 cites W2014311171 @default.
- W2336764732 cites W2029124536 @default.
- W2336764732 cites W2040856583 @default.
- W2336764732 cites W2040966337 @default.
- W2336764732 cites W2055323801 @default.
- W2336764732 cites W2058066470 @default.
- W2336764732 cites W2074035507 @default.
- W2336764732 cites W2074426211 @default.
- W2336764732 cites W2076739494 @default.
- W2336764732 cites W2081272474 @default.
- W2336764732 cites W2096657598 @default.
- W2336764732 cites W2103492381 @default.
- W2336764732 cites W2108745863 @default.
- W2336764732 cites W2122364340 @default.
- W2336764732 cites W2126754939 @default.
- W2336764732 cites W2135078980 @default.
- W2336764732 cites W4243513749 @default.
- W2336764732 doi "https://doi.org/10.1097/scs.0000000000002527" @default.
- W2336764732 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27046469" @default.
- W2336764732 hasPublicationYear "2016" @default.
- W2336764732 type Work @default.
- W2336764732 sameAs 2336764732 @default.
- W2336764732 citedByCount "7" @default.
- W2336764732 countsByYear W23367647322016 @default.
- W2336764732 countsByYear W23367647322017 @default.
- W2336764732 countsByYear W23367647322018 @default.
- W2336764732 countsByYear W23367647322019 @default.
- W2336764732 countsByYear W23367647322020 @default.
- W2336764732 countsByYear W23367647322021 @default.
- W2336764732 countsByYear W23367647322022 @default.
- W2336764732 crossrefType "journal-article" @default.
- W2336764732 hasAuthorship W2336764732A5001180722 @default.
- W2336764732 hasAuthorship W2336764732A5004590637 @default.
- W2336764732 hasAuthorship W2336764732A5008787316 @default.
- W2336764732 hasAuthorship W2336764732A5031600253 @default.
- W2336764732 hasAuthorship W2336764732A5039465001 @default.
- W2336764732 hasAuthorship W2336764732A5047159659 @default.
- W2336764732 hasConcept C105702510 @default.
- W2336764732 hasConcept C126322002 @default.
- W2336764732 hasConcept C126894567 @default.
- W2336764732 hasConcept C141071460 @default.
- W2336764732 hasConcept C199343813 @default.
- W2336764732 hasConcept C2776768464 @default.
- W2336764732 hasConcept C2777397205 @default.
- W2336764732 hasConcept C2778606738 @default.
- W2336764732 hasConcept C2780550940 @default.
- W2336764732 hasConcept C71924100 @default.
- W2336764732 hasConcept C8337478 @default.
- W2336764732 hasConceptScore W2336764732C105702510 @default.
- W2336764732 hasConceptScore W2336764732C126322002 @default.
- W2336764732 hasConceptScore W2336764732C126894567 @default.
- W2336764732 hasConceptScore W2336764732C141071460 @default.
- W2336764732 hasConceptScore W2336764732C199343813 @default.
- W2336764732 hasConceptScore W2336764732C2776768464 @default.
- W2336764732 hasConceptScore W2336764732C2777397205 @default.
- W2336764732 hasConceptScore W2336764732C2778606738 @default.
- W2336764732 hasConceptScore W2336764732C2780550940 @default.
- W2336764732 hasConceptScore W2336764732C71924100 @default.
- W2336764732 hasConceptScore W2336764732C8337478 @default.
- W2336764732 hasIssue "3" @default.
- W2336764732 hasLocation W23367647321 @default.
- W2336764732 hasLocation W23367647322 @default.
- W2336764732 hasOpenAccess W2336764732 @default.
- W2336764732 hasPrimaryLocation W23367647321 @default.
- W2336764732 hasRelatedWork W1989870400 @default.
- W2336764732 hasRelatedWork W2003938723 @default.
- W2336764732 hasRelatedWork W2047967234 @default.
- W2336764732 hasRelatedWork W2118496982 @default.
- W2336764732 hasRelatedWork W2336764732 @default.
- W2336764732 hasRelatedWork W2439875401 @default.
- W2336764732 hasRelatedWork W2889529591 @default.
- W2336764732 hasRelatedWork W4232428403 @default.
- W2336764732 hasRelatedWork W4238867864 @default.
- W2336764732 hasRelatedWork W2525756941 @default.
- W2336764732 hasVolume "27" @default.
- W2336764732 isParatext "false" @default.
- W2336764732 isRetracted "false" @default.
- W2336764732 magId "2336764732" @default.
- W2336764732 workType "article" @default.