FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2336771619> ?p ?o ?g. }

• W2336771619 endingPage "C213" @default.
• W2336771619 startingPage "C206" @default.
• W2336771619 abstract "In previous studies we have shown that rat adipocytes suspended in Matrigel and placed in primary culture migrate through the gel to form multicellular clusters over a 5- to 6-day period. In the present study, phosphorylation of the insulin-regulated 70-kDa ribosomal protein S6 kinase (p70S6k) was observed within 30 min of establishment of adipocytes in primary culture. Two inhibitors of the p70S6k signaling pathway, rapamycin and LY-294002, greatly reduced phosphorylation of p70S6k and organization of adipocytes into multicellular clusters. Of all the components of the cell culture medium, amino acids, and in particular a subset of neutral amino acids, were found to promote both phosphorylation of p70S6k and cluster formation. Lowering the concentrations of amino acids in the medium to levels approximating those in plasma of fasted rats decreased both phosphorylation of p70S6k and cluster formation. Furthermore, stimulation of p70S6k phosphorylation by amino acids was prevented by either rapamycin or LY-294002. These findings demonstrate that amino acids stimulate the p70S6k signaling pathway in adipocytes and imply a role for this pathway in multicellular clustering." @default.
• W2336771619 created "2016-06-24" @default.
• W2336771619 creator A5005861452 @default.
• W2336771619 creator A5042437739 @default.
• W2336771619 creator A5054423139 @default.
• W2336771619 creator A5088274275 @default.
• W2336771619 date "1998-01-01" @default.
• W2336771619 modified "2023-10-15" @default.
• W2336771619 title "Amino acids stimulate phosphorylation of p70^<i>S6k</i>and organization of rat adipocytes into multicellular clusters" @default.
• W2336771619 cites W1490166974 @default.
• W2336771619 cites W1495820232 @default.
• W2336771619 cites W1515071563 @default.
• W2336771619 cites W1538083688 @default.
• W2336771619 cites W1599478288 @default.
• W2336771619 cites W1602103287 @default.
• W2336771619 cites W1620905250 @default.
• W2336771619 cites W1621961391 @default.
• W2336771619 cites W1657005458 @default.
• W2336771619 cites W1947575656 @default.
• W2336771619 cites W1956844386 @default.
• W2336771619 cites W1959535682 @default.
• W2336771619 cites W1965446404 @default.
• W2336771619 cites W1980403683 @default.
• W2336771619 cites W1990612610 @default.
• W2336771619 cites W1993963200 @default.
• W2336771619 cites W1994212260 @default.
• W2336771619 cites W2013381376 @default.
• W2336771619 cites W2015174638 @default.
• W2336771619 cites W2024918809 @default.
• W2336771619 cites W2028365267 @default.
• W2336771619 cites W2044301435 @default.
• W2336771619 cites W2051781413 @default.
• W2336771619 cites W2055341626 @default.
• W2336771619 cites W2058899879 @default.
• W2336771619 cites W2061463166 @default.
• W2336771619 cites W2061959038 @default.
• W2336771619 cites W2069079583 @default.
• W2336771619 cites W2069623607 @default.
• W2336771619 cites W2072876326 @default.
• W2336771619 cites W2092724327 @default.
• W2336771619 cites W2114809267 @default.
• W2336771619 cites W2119159461 @default.
• W2336771619 cites W2135185526 @default.
• W2336771619 cites W2144062999 @default.
• W2336771619 cites W2168534792 @default.
• W2336771619 cites W2341473203 @default.
• W2336771619 cites W2442275722 @default.
• W2336771619 cites W4251148712 @default.
• W2336771619 doi "https://doi.org/10.1152/ajpcell.1998.274.1.c206" @default.
• W2336771619 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9458729" @default.
• W2336771619 hasPublicationYear "1998" @default.
• W2336771619 type Work @default.
• W2336771619 sameAs 2336771619 @default.
• W2336771619 citedByCount "126" @default.
• W2336771619 countsByYear W23367716192012 @default.
• W2336771619 countsByYear W23367716192013 @default.
• W2336771619 countsByYear W23367716192014 @default.
• W2336771619 countsByYear W23367716192015 @default.
• W2336771619 countsByYear W23367716192016 @default.
• W2336771619 countsByYear W23367716192018 @default.
• W2336771619 countsByYear W23367716192019 @default.
• W2336771619 countsByYear W23367716192020 @default.
• W2336771619 countsByYear W23367716192021 @default.
• W2336771619 countsByYear W23367716192022 @default.
• W2336771619 countsByYear W23367716192023 @default.
• W2336771619 crossrefType "journal-article" @default.
• W2336771619 hasAuthorship W2336771619A5005861452 @default.
• W2336771619 hasAuthorship W2336771619A5042437739 @default.
• W2336771619 hasAuthorship W2336771619A5054423139 @default.
• W2336771619 hasAuthorship W2336771619A5088274275 @default.
• W2336771619 hasConcept C104202773 @default.
• W2336771619 hasConcept C11960822 @default.
• W2336771619 hasConcept C2780926556 @default.
• W2336771619 hasConcept C515207424 @default.
• W2336771619 hasConcept C55493867 @default.
• W2336771619 hasConcept C75217442 @default.
• W2336771619 hasConcept C86803240 @default.
• W2336771619 hasConcept C87325107 @default.
• W2336771619 hasConcept C95444343 @default.
• W2336771619 hasConcept C97029542 @default.
• W2336771619 hasConceptScore W2336771619C104202773 @default.
• W2336771619 hasConceptScore W2336771619C11960822 @default.
• W2336771619 hasConceptScore W2336771619C2780926556 @default.
• W2336771619 hasConceptScore W2336771619C515207424 @default.
• W2336771619 hasConceptScore W2336771619C55493867 @default.
• W2336771619 hasConceptScore W2336771619C75217442 @default.
• W2336771619 hasConceptScore W2336771619C86803240 @default.
• W2336771619 hasConceptScore W2336771619C87325107 @default.
• W2336771619 hasConceptScore W2336771619C95444343 @default.
• W2336771619 hasConceptScore W2336771619C97029542 @default.
• W2336771619 hasIssue "1" @default.
• W2336771619 hasLocation W23367716191 @default.
• W2336771619 hasLocation W23367716192 @default.
• W2336771619 hasOpenAccess W2336771619 @default.
• W2336771619 hasPrimaryLocation W23367716191 @default.
• W2336771619 hasRelatedWork W1971707712 @default.
• W2336771619 hasRelatedWork W1982861233 @default.
• W2336771619 hasRelatedWork W2030986659 @default.

• next