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• W2336773383 abstract "There is evidence that certain alleles at the HLA-DQ locus are correlated with susceptibility to insulin-dependent diabetes mellitus (IDDM) and in particular that DQ beta-chain alleles containing aspartic acid at position 57 are protective. The availability of a large group of patients with IDDM enabled us to assess the role of HLA-DQ alleles in susceptibility to the disease in order to confirm and extend recent observations derived from studies of smaller numbers of patients. Using allele-specific oligonucleotide probes and the polymerase chain reaction, we studied 266 unrelated patients with IDDM and 203 unrelated normal subjects for eight HLA-DQ beta-chain alleles." @default.
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• W2336773383 date "1990-06-28" @default.
• W2336773383 modified "2023-10-01" @default.
• W2336773383 title "Analysis of HLA-DQ Genotypes and Susceptibility in Insulin-Dependent Diabetes Mellitus" @default.
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• W2336773383 doi "https://doi.org/10.1056/nejm199006283222602" @default.
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