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• W2336797911 abstract "Abstract Small RNA-induced gene silencing is essential for post-transcriptional regulation of gene expression; however, it remains unclear how miRNA/siRNA efficiency is regulated. Here we show that TARBP2 is SUMOylated at K52, which can be enhanced by its phosphorylation. This modification can stabilize TARBP2 via repressing its K 48 -linked ubiquitination. We find that TARBP2 SUMOylation does not influence the overall production of mature miRNAs, but it regulates miRNA/siRNA efficiency. SUMOylated TARBP2 recruits Ago2 to constitute the RNA-induced silencing complex (RISC)-loading complex (RLC), and simultaneously promotes more pre-miRNAs to load into the RLC. Consequently, Ago2 is stabilized and miRNAs/siRNAs bound by TARBP2/Dicer is effectively transferred to Ago2. Thus, these processes lead to the formation of the effective RISC for RNA interference (RNAi). Collectively, our data suggest that SUMOylation of TARBP2 is required for regulating miRNA/siRNA efficiency, which is a general mechanism of miRNA/siRNA regulation." @default.
• W2336797911 created "2016-06-24" @default.
• W2336797911 creator A5007078745 @default.
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• W2336797911 date "2015-11-19" @default.
• W2336797911 modified "2023-09-23" @default.
• W2336797911 title "SUMOylation of TARBP2 regulates miRNA/siRNA efficiency" @default.
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• W2336797911 doi "https://doi.org/10.1038/ncomms9899" @default.
• W2336797911 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4673853" @default.
• W2336797911 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26582366" @default.
• W2336797911 hasPublicationYear "2015" @default.
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