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- W2336807314 abstract "目的：研究儿茶酚异喹啉类物质1-甲基-6,7-二羟基-1,2,3,4-四氢异喹啉（salsolinol,Sal）对帕金森病关键蛋白α突触核蛋白（α-syulcein,α-syn）纤维化程度的影响。方法：将重组人源α-Syn蛋白与不同浓度的Sal共同孵育,通过ThT染色对α-Syn成纤维状况进行监测。同时,利用扫描电镜和激光共聚焦显微镜观察α-Syn与Sal共孵育后的形态变化。结果／结论：实验结果表明Sal具有将α-Syn稳定在寡聚体或者原纤维状态的能力,且呈浓度依赖性,Sal浓度越大,α-Syn纤维化进程越缓慢。这一发现为进一步研究α-Syn和儿茶酚异喹啉类物质在PD发生和发展过程中起到的作用提供了一定的实验依据。" @default.
- W2336807314 created "2016-06-24" @default.
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- W2336807314 date "2015-01-01" @default.
- W2336807314 modified "2023-09-27" @default.
- W2336807314 title "儿茶酚异喹啉类物质Salsolinol（Sal）对α-Syn纤维化程度的影响" @default.
- W2336807314 hasPublicationYear "2015" @default.
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