Matches in SemOpenAlex for { <https://semopenalex.org/work/W2337023143> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2337023143 endingPage "F235" @default.
- W2337023143 startingPage "F225" @default.
- W2337023143 abstract "Clearance experiments were performed in anesthetized male Wistar rats to determine the level of peripheral glucagon concentration required to elicit changes in glomerular filtration rate (GFR) and in solute excretion. Glucagon was intravenously infused at a rate of 1.25 (group G-1, n = 8), 3.75 (group G-3, n = 7), or 12.5 (group G-10, n = 7) ng.min-1.100 g body wt-1 for 100 min. Measurements were performed before, during, and after this infusion. Group G-10 resulted in a plasma concentration of glucagon severalfold higher than usually observed in peripheral blood after a protein meal but normal for the hepatic circulation. Group G-10 simultaneously increased GFR, plasma adenosine 3',5'-cyclic monophosphate (cAMP) concentration, and the excretion of water (i.e., urinary flow rate), Na, Cl, PO4, K, and urea. Some of the effects of glucagon on electrolyte excretion were also observed with group G-1 and/or G-3 and were fully reversible, suggesting a direct renal action of glucagon. The significant and reversible increase in K excretion in group G-3 suggests that glucagon exerts a direct stimulatory influence on K secretion in the distal nephron. Increases in urinary flow rate, PO4, Na, and urea fractional excretions were seen with group G-10 only and were not reversible, suggesting an indirect action of glucagon on the proximal tubule. Because glucagon stimulates cAMP formation in hepatocytes and because this cAMP is released in the blood and secreted by proximal tubule cells, cAMP of hepatic origin could induce a parathyroid hormone-like effect in this nephron segment. In summary, these experiments suggest that glucagon influences different aspects of renal function by a combination of direct and indirect (probably liver-dependent) effects." @default.
- W2337023143 created "2016-06-24" @default.
- W2337023143 creator A5012095540 @default.
- W2337023143 creator A5026204879 @default.
- W2337023143 creator A5041710834 @default.
- W2337023143 creator A5081461751 @default.
- W2337023143 date "1995-08-01" @default.
- W2337023143 modified "2023-09-30" @default.
- W2337023143 title "Influence of glucagon on GFR and on urea and electrolyte excretion: direct and indirect effects" @default.
- W2337023143 doi "https://doi.org/10.1152/ajprenal.1995.269.2.f225" @default.
- W2337023143 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7653596" @default.
- W2337023143 hasPublicationYear "1995" @default.
- W2337023143 type Work @default.
- W2337023143 sameAs 2337023143 @default.
- W2337023143 citedByCount "25" @default.
- W2337023143 countsByYear W23370231432012 @default.
- W2337023143 countsByYear W23370231432014 @default.
- W2337023143 countsByYear W23370231432015 @default.
- W2337023143 countsByYear W23370231432016 @default.
- W2337023143 countsByYear W23370231432018 @default.
- W2337023143 countsByYear W23370231432019 @default.
- W2337023143 countsByYear W23370231432020 @default.
- W2337023143 countsByYear W23370231432021 @default.
- W2337023143 countsByYear W23370231432023 @default.
- W2337023143 crossrefType "journal-article" @default.
- W2337023143 hasAuthorship W2337023143A5012095540 @default.
- W2337023143 hasAuthorship W2337023143A5026204879 @default.
- W2337023143 hasAuthorship W2337023143A5041710834 @default.
- W2337023143 hasAuthorship W2337023143A5081461751 @default.
- W2337023143 hasConcept C10146269 @default.
- W2337023143 hasConcept C126322002 @default.
- W2337023143 hasConcept C134018914 @default.
- W2337023143 hasConcept C159641895 @default.
- W2337023143 hasConcept C185592680 @default.
- W2337023143 hasConcept C2778563252 @default.
- W2337023143 hasConcept C2780091579 @default.
- W2337023143 hasConcept C2780365088 @default.
- W2337023143 hasConcept C55493867 @default.
- W2337023143 hasConcept C71315377 @default.
- W2337023143 hasConcept C71924100 @default.
- W2337023143 hasConcept C86803240 @default.
- W2337023143 hasConceptScore W2337023143C10146269 @default.
- W2337023143 hasConceptScore W2337023143C126322002 @default.
- W2337023143 hasConceptScore W2337023143C134018914 @default.
- W2337023143 hasConceptScore W2337023143C159641895 @default.
- W2337023143 hasConceptScore W2337023143C185592680 @default.
- W2337023143 hasConceptScore W2337023143C2778563252 @default.
- W2337023143 hasConceptScore W2337023143C2780091579 @default.
- W2337023143 hasConceptScore W2337023143C2780365088 @default.
- W2337023143 hasConceptScore W2337023143C55493867 @default.
- W2337023143 hasConceptScore W2337023143C71315377 @default.
- W2337023143 hasConceptScore W2337023143C71924100 @default.
- W2337023143 hasConceptScore W2337023143C86803240 @default.
- W2337023143 hasIssue "2" @default.
- W2337023143 hasLocation W23370231431 @default.
- W2337023143 hasLocation W23370231432 @default.
- W2337023143 hasOpenAccess W2337023143 @default.
- W2337023143 hasPrimaryLocation W23370231431 @default.
- W2337023143 hasRelatedWork W1987976051 @default.
- W2337023143 hasRelatedWork W2033052007 @default.
- W2337023143 hasRelatedWork W2067188704 @default.
- W2337023143 hasRelatedWork W2070046754 @default.
- W2337023143 hasRelatedWork W2073527559 @default.
- W2337023143 hasRelatedWork W2092293385 @default.
- W2337023143 hasRelatedWork W2092767995 @default.
- W2337023143 hasRelatedWork W2145722810 @default.
- W2337023143 hasRelatedWork W2157523186 @default.
- W2337023143 hasRelatedWork W2331234043 @default.
- W2337023143 hasVolume "269" @default.
- W2337023143 isParatext "false" @default.
- W2337023143 isRetracted "false" @default.
- W2337023143 magId "2337023143" @default.
- W2337023143 workType "article" @default.