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- W2337097230 abstract "(13%). The median time to treatment failure was 7 months, and median survival duration was 17 months. The limiting toxicity was myelosuppression, mainly leukopenia in 49 patients (100%) (grade 1 to grade 2, four patients; grade 3, 30 patients; and grade 4, 15 patients). Neutropenia was observed in 100% of patients (grade 1 to grade 2, three patients; grade 3, 11 patients; grade 4, 35 patients). Two treatment-related deaths due to febrile neutropenia were observed in patients with massive liver involvement. Peripheral neurotoxicity developed in 33 patients (67%) (grade 1, 25 patients; grade 2, eight patients); there were no grade 3 or grade 4 episodes. Conclusion: The combination of VNB-PTX showed significant activity as first-line chemotherapy for patients with MBC. Myelosuppression was the doselimiting side effect, whereas neurotoxicity was mild to moderate. J Clin Oncol 17:74-81. r 1999 by American Society of Clinical Oncology." @default.
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- W2337097230 title "Vinorelbine a nd P aclitaxel a s F irst-Line C hemotherapy in M etastatic B reast C ancer" @default.
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