Matches in SemOpenAlex for { <https://semopenalex.org/work/W2337100441> ?p ?o ?g. }
- W2337100441 endingPage "544" @default.
- W2337100441 startingPage "534" @default.
- W2337100441 abstract "There has been increasing focus on generation and assessment of in vitro developmental toxicology models for assessing teratogenic liability of chemicals. The driver for this focus has been to find reliable in vitro assays that will reduce or replace the use of in vivo tests for assessing teratogenicity. Such efforts may be eventually applied in testing pharmaceutical agents where a developmental toxicology assay or battery of assays may be incorporated into regulatory testing to replace one of the two species currently used in teratogenic assessment. Such assays may be eventually applied in testing a broader spectrum of chemicals, supporting efforts aligned with Tox21 strategies and responding to REACH legislation. This review describes the developmental toxicology assays that are of focus in these assessments: rodent whole embryo culture, zebrafish embryo assays, and embryonic stem cell assays. Progress on assay development as well as future directions of how these assays are envisioned to be applied for broader safety testing of chemicals are discussed. Altogether, the developmental model systems described in this review provide rich biological systems that can be utilized in better understanding teratogenic mechanisms of action of chemotypes and are promising in providing proactive safety assessment related to developmental toxicity. Continual advancements in refining/optimizing these in vitro assays are anticipated to provide a robust data set to provide thoughtful assessment of how whole animal teratogenicity evaluations can be reduced/refined in the future." @default.
- W2337100441 created "2016-06-24" @default.
- W2337100441 creator A5005593188 @default.
- W2337100441 creator A5028057592 @default.
- W2337100441 creator A5059725625 @default.
- W2337100441 creator A5063411435 @default.
- W2337100441 date "2016-02-01" @default.
- W2337100441 modified "2023-09-23" @default.
- W2337100441 title "<i>In Vitro</i> Developmental Toxicology Screens: A Report on the Progress of the Methodology and Future Applications" @default.
- W2337100441 cites W1574731223 @default.
- W2337100441 cites W1579194856 @default.
- W2337100441 cites W1770292777 @default.
- W2337100441 cites W1948938001 @default.
- W2337100441 cites W1966448485 @default.
- W2337100441 cites W1966873819 @default.
- W2337100441 cites W1971036442 @default.
- W2337100441 cites W1973461367 @default.
- W2337100441 cites W1975431773 @default.
- W2337100441 cites W1976148540 @default.
- W2337100441 cites W1977122905 @default.
- W2337100441 cites W1978053825 @default.
- W2337100441 cites W1980642761 @default.
- W2337100441 cites W1981239255 @default.
- W2337100441 cites W1984083105 @default.
- W2337100441 cites W1985827391 @default.
- W2337100441 cites W1987774343 @default.
- W2337100441 cites W1991671862 @default.
- W2337100441 cites W1997427091 @default.
- W2337100441 cites W1999383862 @default.
- W2337100441 cites W1999420091 @default.
- W2337100441 cites W2003433437 @default.
- W2337100441 cites W2012777643 @default.
- W2337100441 cites W20181848 @default.
- W2337100441 cites W2029955364 @default.
- W2337100441 cites W2030406325 @default.
- W2337100441 cites W2031323776 @default.
- W2337100441 cites W2033183212 @default.
- W2337100441 cites W2034652895 @default.
- W2337100441 cites W2038576120 @default.
- W2337100441 cites W2041473955 @default.
- W2337100441 cites W2048609535 @default.
- W2337100441 cites W2050886615 @default.
- W2337100441 cites W2052451267 @default.
- W2337100441 cites W2055154858 @default.
- W2337100441 cites W2058491374 @default.
- W2337100441 cites W2059378220 @default.
- W2337100441 cites W2062384549 @default.
- W2337100441 cites W2067011924 @default.
- W2337100441 cites W2072569268 @default.
- W2337100441 cites W2076289536 @default.
- W2337100441 cites W2083763893 @default.
- W2337100441 cites W2083972442 @default.
- W2337100441 cites W2095404170 @default.
- W2337100441 cites W2096482948 @default.
- W2337100441 cites W2099692128 @default.
- W2337100441 cites W2103906886 @default.
- W2337100441 cites W2104155874 @default.
- W2337100441 cites W2105623987 @default.
- W2337100441 cites W2112260651 @default.
- W2337100441 cites W2118852675 @default.
- W2337100441 cites W2119885620 @default.
- W2337100441 cites W2122025333 @default.
- W2337100441 cites W2122877713 @default.
- W2337100441 cites W2123308898 @default.
- W2337100441 cites W2129307978 @default.
- W2337100441 cites W2133793464 @default.
- W2337100441 cites W2144323524 @default.
- W2337100441 cites W2149902366 @default.
- W2337100441 cites W2152366943 @default.
- W2337100441 cites W2153498867 @default.
- W2337100441 cites W2155016057 @default.
- W2337100441 cites W2157253468 @default.
- W2337100441 cites W2162142896 @default.
- W2337100441 cites W2163651529 @default.
- W2337100441 cites W2166599552 @default.
- W2337100441 cites W2170111436 @default.
- W2337100441 cites W2232521592 @default.
- W2337100441 cites W2261258724 @default.
- W2337100441 cites W2404597399 @default.
- W2337100441 cites W2419057020 @default.
- W2337100441 cites W27814405 @default.
- W2337100441 cites W4245171350 @default.
- W2337100441 doi "https://doi.org/10.1021/acs.chemrestox.5b00458" @default.
- W2337100441 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26766213" @default.
- W2337100441 hasPublicationYear "2016" @default.
- W2337100441 type Work @default.
- W2337100441 sameAs 2337100441 @default.
- W2337100441 citedByCount "22" @default.
- W2337100441 countsByYear W23371004412016 @default.
- W2337100441 countsByYear W23371004412017 @default.
- W2337100441 countsByYear W23371004412018 @default.
- W2337100441 countsByYear W23371004412019 @default.
- W2337100441 countsByYear W23371004412020 @default.
- W2337100441 countsByYear W23371004412021 @default.
- W2337100441 countsByYear W23371004412023 @default.
- W2337100441 crossrefType "journal-article" @default.
- W2337100441 hasAuthorship W2337100441A5005593188 @default.
- W2337100441 hasAuthorship W2337100441A5028057592 @default.