Matches in SemOpenAlex for { <https://semopenalex.org/work/W2337102023> ?p ?o ?g. }
- W2337102023 endingPage "238" @default.
- W2337102023 startingPage "209" @default.
- W2337102023 abstract "The methylation of lysine and arginine residues on histones plays a pivotal role in the organization of the chromatin fiber, the regulation of gene expression, and cellular differentiation. Recently, genetic aberrations in the enzymes controlling these posttranslational modifications, histone methyltransferases and demethylases, have been discovered in different types of cancer, together with alterations in global and locus-specific histone methylation. These observations have attracted much attention toward the development of chemical probes and epigenetic drugs targeting histone methyltransferases and demethylases. Here, we describe global and local features of histone methylation together with assays developed for the assessment of this posttranslational modification. Finally, we illustrate ten different ways to target histone methylation providing examples of small molecule inhibitors engaging some of the hottest epigenetic targets." @default.
- W2337102023 created "2016-06-24" @default.
- W2337102023 creator A5025140172 @default.
- W2337102023 creator A5084485181 @default.
- W2337102023 date "2016-01-01" @default.
- W2337102023 modified "2023-09-23" @default.
- W2337102023 title "Targeting Histone Methylation" @default.
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